The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders
Background Hypomanic symptoms may be a useful predictor of mood disorder among young people at high risk for bipolar disorder. Aims To determine whether hypomanic symptoms differentiate offspring of p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2017-03-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472400002040/type/journal_article |
| _version_ | 1811157061127372800 |
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| author | Sarah Margaret Goodday Martin Preisig Mehdi Gholamrezaee Paul Grof Jules Angst Anne Duffy |
| author_facet | Sarah Margaret Goodday Martin Preisig Mehdi Gholamrezaee Paul Grof Jules Angst Anne Duffy |
| author_sort | Sarah Margaret Goodday |
| collection | DOAJ |
| description |
Background
Hypomanic symptoms may be a useful predictor of mood disorder among young people at high risk for bipolar disorder.
Aims
To determine whether hypomanic symptoms differentiate offspring of parents with bipolar disorder (high risk) and offspring of well parents (control) and predict the development of mood episodes.
Method
High-risk and control offspring were prospectively assessed using semi-structured clinical interviews annually and completed the Hypomania Checklist-32 Revised (HCL-32). Clinically significant sub-threshold hypomanic symptoms (CSHS) were coded.
Results
HCL-32 total and active or elated scores were higher in control compared with high-risk offspring, whereas 14% of high-risk and 0% of control offspring had CSHS. High-risk offspring with CSHS had a fivefold increased risk of developing recurrent major depression (P=0.0002). The median onset of CSHS in high-risk offspring was 16.4 (6–31) years and was before the onset of major mood episodes.
Conclusions
CSHS are precursors to major mood episodes in high-risk offspring and could identify individuals at ultra-high risk for developing bipolar disorder.
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| first_indexed | 2024-04-10T05:00:59Z |
| format | Article |
| id | doaj.art-09acd12065f248e1ab3e68f650eea17b |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T05:00:59Z |
| publishDate | 2017-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-09acd12065f248e1ab3e68f650eea17b2023-03-09T12:28:40ZengCambridge University PressBJPsych Open2056-47242017-03-013717710.1192/bjpo.bp.116.004234The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disordersSarah Margaret Goodday0Martin Preisig1Mehdi Gholamrezaee2Paul Grof3Jules Angst4Anne Duffy5Department of Epidemiology, University of Toronto, Toronto, Ontario, CanadaPsychiatric University Hospital of Lausanne, Lausanne, SwitzerlandPsychiatric University Hospital of Lausanne, Lausanne, SwitzerlandDepartment of Psychiatry, University of Toronto, Toronto, Ontario, Canada, and Mood Disorders Centre of Ottawa, Ottawa, Ontario, CanadaDepartment of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, SwitzerlandMood Disorders Centre of Ottawa, Ottawa, Ontario, Canada, and Department of Psychiatry, Queen's University, Kingston, Ontario, Canada Background Hypomanic symptoms may be a useful predictor of mood disorder among young people at high risk for bipolar disorder. Aims To determine whether hypomanic symptoms differentiate offspring of parents with bipolar disorder (high risk) and offspring of well parents (control) and predict the development of mood episodes. Method High-risk and control offspring were prospectively assessed using semi-structured clinical interviews annually and completed the Hypomania Checklist-32 Revised (HCL-32). Clinically significant sub-threshold hypomanic symptoms (CSHS) were coded. Results HCL-32 total and active or elated scores were higher in control compared with high-risk offspring, whereas 14% of high-risk and 0% of control offspring had CSHS. High-risk offspring with CSHS had a fivefold increased risk of developing recurrent major depression (P=0.0002). The median onset of CSHS in high-risk offspring was 16.4 (6–31) years and was before the onset of major mood episodes. Conclusions CSHS are precursors to major mood episodes in high-risk offspring and could identify individuals at ultra-high risk for developing bipolar disorder. https://www.cambridge.org/core/product/identifier/S2056472400002040/type/journal_article |
| spellingShingle | Sarah Margaret Goodday Martin Preisig Mehdi Gholamrezaee Paul Grof Jules Angst Anne Duffy The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders BJPsych Open |
| title | The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders |
| title_full | The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders |
| title_fullStr | The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders |
| title_full_unstemmed | The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders |
| title_short | The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders |
| title_sort | association between self reported and clinically determined hypomanic symptoms and the onset of major mood disorders |
| url | https://www.cambridge.org/core/product/identifier/S2056472400002040/type/journal_article |
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