Multi-faceted regulation of IgE production and humoral memory formation
IgE antibodies play a protective role against parasites and environmental toxins by its strong effector functions. However, aberrant IgE production can contribute to the development of allergic disorders, and thus is tightly regulated. Beside its very short half-life, IgE is normally produced only t...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-04-01
|
| Series: | Allergology International |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893020301465 |
| _version_ | 1818353369632210944 |
|---|---|
| author | Kei Haniuda Daisuke Kitamura |
| author_facet | Kei Haniuda Daisuke Kitamura |
| author_sort | Kei Haniuda |
| collection | DOAJ |
| description | IgE antibodies play a protective role against parasites and environmental toxins by its strong effector functions. However, aberrant IgE production can contribute to the development of allergic disorders, and thus is tightly regulated. Beside its very short half-life, IgE is normally produced only transiently and its affinity maturation is limited under physiological immune responses. Although such distinct characteristics of IgE among Ig classes are well-known, the underlying molecular mechanisms have not been understood until recently. Somatic or genetic defects of such mechanisms can lead to pathogenesis of allergic diseases. In this review, we summarize recent advances in our understanding of the mechanisms that control the production of IgE and formation of IgE-type humoral memory, focusing on the B cell immune responses. |
| first_indexed | 2024-12-13T19:08:26Z |
| format | Article |
| id | doaj.art-09ad6ae1c43b43519189ae32dd514df8 |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-13T19:08:26Z |
| publishDate | 2021-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-09ad6ae1c43b43519189ae32dd514df82022-12-21T23:34:28ZengElsevierAllergology International1323-89302021-04-01702163168Multi-faceted regulation of IgE production and humoral memory formationKei Haniuda0Daisuke Kitamura1Corresponding author. Research Institute for Biomedical Sciences, Tokyo University of Science, Yamazaki 2669, Noda, Chiba 278-0022, Japan.; Division of Molecular Biology, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Chiba, JapanDivision of Molecular Biology, Research Institute for Biomedical Sciences (RIBS), Tokyo University of Science, Chiba, JapanIgE antibodies play a protective role against parasites and environmental toxins by its strong effector functions. However, aberrant IgE production can contribute to the development of allergic disorders, and thus is tightly regulated. Beside its very short half-life, IgE is normally produced only transiently and its affinity maturation is limited under physiological immune responses. Although such distinct characteristics of IgE among Ig classes are well-known, the underlying molecular mechanisms have not been understood until recently. Somatic or genetic defects of such mechanisms can lead to pathogenesis of allergic diseases. In this review, we summarize recent advances in our understanding of the mechanisms that control the production of IgE and formation of IgE-type humoral memory, focusing on the B cell immune responses.http://www.sciencedirect.com/science/article/pii/S1323893020301465B cellB-cell receptorGerminal centerHumoral memoryIgE |
| spellingShingle | Kei Haniuda Daisuke Kitamura Multi-faceted regulation of IgE production and humoral memory formation Allergology International B cell B-cell receptor Germinal center Humoral memory IgE |
| title | Multi-faceted regulation of IgE production and humoral memory formation |
| title_full | Multi-faceted regulation of IgE production and humoral memory formation |
| title_fullStr | Multi-faceted regulation of IgE production and humoral memory formation |
| title_full_unstemmed | Multi-faceted regulation of IgE production and humoral memory formation |
| title_short | Multi-faceted regulation of IgE production and humoral memory formation |
| title_sort | multi faceted regulation of ige production and humoral memory formation |
| topic | B cell B-cell receptor Germinal center Humoral memory IgE |
| url | http://www.sciencedirect.com/science/article/pii/S1323893020301465 |
| work_keys_str_mv | AT keihaniuda multifacetedregulationofigeproductionandhumoralmemoryformation AT daisukekitamura multifacetedregulationofigeproductionandhumoralmemoryformation |