Trypanosoma cruzi: Correlations of Biological Aspects of the Life Cycle in Mice and Triatomines
The infection pattern in Swiss mice and Triatomine bugs (Rhodnius neglectus) of eleven clones and the original stock of a Trypanosoma cruzi isolate, derived from a naturally infected Didelphis marsupialis, were biochemically and biologically characterized. The clones and the original isolate were in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1999-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000300021 |
| _version_ | 1797756951590862848 |
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| author | Lima Valdirene S Mangia Regina HR Carreira João C Marchewski Renato S Jansen Ana M |
| author_facet | Lima Valdirene S Mangia Regina HR Carreira João C Marchewski Renato S Jansen Ana M |
| author_sort | Lima Valdirene S |
| collection | DOAJ |
| description | The infection pattern in Swiss mice and Triatomine bugs (Rhodnius neglectus) of eleven clones and the original stock of a Trypanosoma cruzi isolate, derived from a naturally infected Didelphis marsupialis, were biochemically and biologically characterized. The clones and the original isolate were in the same zymodeme (Z1) except that two clones were found to be in zymodeme 2 when tested with G6PDH. Although infective, neither the original isolate nor the clones were highly virulent for the mice and lesions were only observed in mice infected with the original stock and one of the clones (F8). All clones and the original isolate infected bugs well while only the original isolate and clones E2 and F3 yielded high metacyclogenesis rates. An observed correlation between absence of lesions in the mammal host and high metacyclogenesis rates in the invertebrate host suggest a evolutionary trade off i.e. a fitness increase in one trait which is accompanied by a fitness reduction in a different one. Our results suggest that in a species as heterogeneous as T. cruzi, a cooperation effect among the subpopulations should be considered. |
| first_indexed | 2024-03-12T18:08:58Z |
| format | Article |
| id | doaj.art-09ae7bbf8f784491a1de18d1183d7847 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:08:58Z |
| publishDate | 1999-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-09ae7bbf8f784491a1de18d1183d78472023-08-02T09:16:35ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601999-01-01943397402Trypanosoma cruzi: Correlations of Biological Aspects of the Life Cycle in Mice and TriatominesLima Valdirene SMangia Regina HRCarreira João CMarchewski Renato SJansen Ana MThe infection pattern in Swiss mice and Triatomine bugs (Rhodnius neglectus) of eleven clones and the original stock of a Trypanosoma cruzi isolate, derived from a naturally infected Didelphis marsupialis, were biochemically and biologically characterized. The clones and the original isolate were in the same zymodeme (Z1) except that two clones were found to be in zymodeme 2 when tested with G6PDH. Although infective, neither the original isolate nor the clones were highly virulent for the mice and lesions were only observed in mice infected with the original stock and one of the clones (F8). All clones and the original isolate infected bugs well while only the original isolate and clones E2 and F3 yielded high metacyclogenesis rates. An observed correlation between absence of lesions in the mammal host and high metacyclogenesis rates in the invertebrate host suggest a evolutionary trade off i.e. a fitness increase in one trait which is accompanied by a fitness reduction in a different one. Our results suggest that in a species as heterogeneous as T. cruzi, a cooperation effect among the subpopulations should be considered.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000300021Trypanosoma cruziRhodnius prolixushistopathologylife cycleclone-trade-off |
| spellingShingle | Lima Valdirene S Mangia Regina HR Carreira João C Marchewski Renato S Jansen Ana M Trypanosoma cruzi: Correlations of Biological Aspects of the Life Cycle in Mice and Triatomines Memorias do Instituto Oswaldo Cruz Trypanosoma cruzi Rhodnius prolixus histopathology life cycle clone-trade-off |
| title | Trypanosoma cruzi: Correlations of Biological Aspects of the Life Cycle in Mice and Triatomines |
| title_full | Trypanosoma cruzi: Correlations of Biological Aspects of the Life Cycle in Mice and Triatomines |
| title_fullStr | Trypanosoma cruzi: Correlations of Biological Aspects of the Life Cycle in Mice and Triatomines |
| title_full_unstemmed | Trypanosoma cruzi: Correlations of Biological Aspects of the Life Cycle in Mice and Triatomines |
| title_short | Trypanosoma cruzi: Correlations of Biological Aspects of the Life Cycle in Mice and Triatomines |
| title_sort | trypanosoma cruzi correlations of biological aspects of the life cycle in mice and triatomines |
| topic | Trypanosoma cruzi Rhodnius prolixus histopathology life cycle clone-trade-off |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761999000300021 |
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