Isoaaptamine increases ROS levels causing autophagy and mitochondria-mediated apoptosis in glioblastoma multiforme cells

Isoaaptamine increases ROS levels causing autophagy and mitochondria-mediated apoptosis in glioblastoma multiforme cells

Glioblastoma multiforme (GBM) is a common central nervous system disease with a poor prognosis; its five-year survival rate is <5 %, and its median survival of 15 months. Current treatment includes chemotherapy with temozolomide, which is ineffective against GBM, suggesting an urgent need to deve...

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Bibliographic Details
Main Authors: Zhi-Hong Wen, Hsiao-Mei Kuo, Po-Chang Shih, Ling-Chen Hsu, Jimmy Ming-Jung Chuang, Nan-Fu Chen, Hsi-Wen Sun, Hsin-Tzu Liu, Chun-Sung Sung, Wu-Fu Chen
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Natural product
Mitochondria
Apoptosis
Autophagy
Isoaaptamine
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223001476

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223001476

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