T Cell Activating Thermostable Self‐Assembly Nanoscaffold Tailored for Cellular Immunity Antigen Delivery

T Cell Activating Thermostable Self‐Assembly Nanoscaffold Tailored for Cellular Immunity Antigen Delivery

Abstract Antigen delivery based on non‐virus‐like particle self‐associating protein nanoscffolds, such as Aquifex aeolicus lumazine synthase (AaLS), is limited due to the immunotoxicity and/or premature clearance of antigen‐scaffold complex resulted from triggering unregulated innate immune response...

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Bibliographic Details
Main Authors: Jinsong Zhang, Jianghua Yang, Qianlin Li, Ruihao Peng, Shoudong Fan, Huaimin Yi, Yuying Lu, Yuanli Peng, Haozhen Yan, Lidan Sun, Jiahai Lu, Zeliang Chen
Format: Article
Language:English
Published: Wiley 2023-09-01
Series:Advanced Science
Subjects:
antigen delivery
protein engineering
self‐assembly
T cell‐mediated immunity
thermostable nanoscaffold
Online Access:https://doi.org/10.1002/advs.202303049

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