Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT in Obese Patients
Introduction: The emerging role of the 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in the study of the metabolic activity and inflammation in adipose tissue indicates that it might be a reliable tool to complement the risk stratification in obesity. The aims of this study...
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| Language: | English |
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Ordem dos Médicos
2017-11-01
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| Series: | Acta Médica Portuguesa |
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| Online Access: | http://actamedicaportuguesa.com/revista/index.php/amp/article/view/8712 |
| _version_ | 1818956500977057792 |
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| author | Ana Margarida Monteiro Gonçalo Ferreira Hugo Duarte |
| author_facet | Ana Margarida Monteiro Gonçalo Ferreira Hugo Duarte |
| author_sort | Ana Margarida Monteiro |
| collection | DOAJ |
| description | Introduction: The emerging role of the 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in the study of the metabolic activity and inflammation in adipose tissue indicates that it might be a reliable tool to complement the risk stratification in obesity. The aims of this study were the evaluation of 18F-fluorodeoxyglucose uptake by visceral adipose tissues and subcutaneous adipose tissues and to determine eventual differences in patients with and without obesity.
Material and Methods: Retrospective study of adult patients who underwent whole body 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography scanning between July and August of 2016. Statistical analysis: SPSS™ software v.20. Statistical
significance: p < 0.05.
Results: We assessed fluorodeoxyglucose-positron emission tomography/computed tomography scans from 156 patients (58.3% of males) with a mean age of 61.0 ± 14.1 years. Half of the patients had a body mass index ≥ 25.0 kg/m2 and 15.4% (n = 24) were obese. In both groups, the mean 18F-fluorodeoxyglucose uptake was higher in visceral adipose tissues. There were no differences in 18F-fluorodeoxyglucose uptake in visceral adipose tissues between the groups. Obese patients had lower density of adipose tissue,
both in subcutaneous adipose tissues and in visceral adipose tissues. Abdominal circumference and density of visceral adipose tissues
had a positive predictive value in the mean 18F-fluorodeoxyglucose uptake in visceral adipose tissues.
Discussion: Through a non-invasive test, this study demonstrated a significant higher metabolic activity in visceral adipose tissues in both obese and non-obese patients. According to our results, abdominal circumference was an important determinant in 18F-fluorodeoxyglucose uptake in visceral adipose tissues. We also demonstrated that obese patients had differences in adipose tissue quality.
Conclusion: Our findings reinforce the importance of the adipose tissue quality and distribution for metabolic risk stratification. |
| first_indexed | 2024-12-20T10:54:57Z |
| format | Article |
| id | doaj.art-09b6faf9611b4be5a3a2f7fd5159dc36 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-12-20T10:54:57Z |
| publishDate | 2017-11-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-09b6faf9611b4be5a3a2f7fd5159dc362022-12-21T19:43:10ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582017-11-01301181381710.20344/amp.87124611Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT in Obese PatientsAna Margarida Monteiro0Gonçalo Ferreira1Hugo Duarte2Serviço de Endocrinologia. Hospital de Braga. Braga. Portugal.Serviço de Medicina Nuclear. Instituto Português de Oncologia do Porto. Porto. Portugal.Serviço de Medicina Nuclear. Instituto Português de Oncologia do Porto. Porto. Portugal.Introduction: The emerging role of the 18F-fluorodeoxyglucose-positron emission tomography/computed tomography in the study of the metabolic activity and inflammation in adipose tissue indicates that it might be a reliable tool to complement the risk stratification in obesity. The aims of this study were the evaluation of 18F-fluorodeoxyglucose uptake by visceral adipose tissues and subcutaneous adipose tissues and to determine eventual differences in patients with and without obesity. Material and Methods: Retrospective study of adult patients who underwent whole body 18F-fluorodeoxyglucose-positron emission tomography/ computed tomography scanning between July and August of 2016. Statistical analysis: SPSS™ software v.20. Statistical significance: p < 0.05. Results: We assessed fluorodeoxyglucose-positron emission tomography/computed tomography scans from 156 patients (58.3% of males) with a mean age of 61.0 ± 14.1 years. Half of the patients had a body mass index ≥ 25.0 kg/m2 and 15.4% (n = 24) were obese. In both groups, the mean 18F-fluorodeoxyglucose uptake was higher in visceral adipose tissues. There were no differences in 18F-fluorodeoxyglucose uptake in visceral adipose tissues between the groups. Obese patients had lower density of adipose tissue, both in subcutaneous adipose tissues and in visceral adipose tissues. Abdominal circumference and density of visceral adipose tissues had a positive predictive value in the mean 18F-fluorodeoxyglucose uptake in visceral adipose tissues. Discussion: Through a non-invasive test, this study demonstrated a significant higher metabolic activity in visceral adipose tissues in both obese and non-obese patients. According to our results, abdominal circumference was an important determinant in 18F-fluorodeoxyglucose uptake in visceral adipose tissues. We also demonstrated that obese patients had differences in adipose tissue quality. Conclusion: Our findings reinforce the importance of the adipose tissue quality and distribution for metabolic risk stratification.http://actamedicaportuguesa.com/revista/index.php/amp/article/view/8712Adipose Tissue/diagnostic imagingFluorodeoxyglucose F18Intra-Abdominal Fat/diagnostic imagingObesity/diagnostic imagingPositron-Emission TomographySubcutaneous Fat/diagnostic imaging |
| spellingShingle | Ana Margarida Monteiro Gonçalo Ferreira Hugo Duarte Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT in Obese Patients Acta Médica Portuguesa Adipose Tissue/diagnostic imaging Fluorodeoxyglucose F18 Intra-Abdominal Fat/diagnostic imaging Obesity/diagnostic imaging Positron-Emission Tomography Subcutaneous Fat/diagnostic imaging |
| title | Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT in Obese Patients |
| title_full | Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT in Obese Patients |
| title_fullStr | Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT in Obese Patients |
| title_full_unstemmed | Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT in Obese Patients |
| title_short | Metabolic Activity in the Visceral and Subcutaneous Adipose Tissues by FDG-PET/CT in Obese Patients |
| title_sort | metabolic activity in the visceral and subcutaneous adipose tissues by fdg pet ct in obese patients |
| topic | Adipose Tissue/diagnostic imaging Fluorodeoxyglucose F18 Intra-Abdominal Fat/diagnostic imaging Obesity/diagnostic imaging Positron-Emission Tomography Subcutaneous Fat/diagnostic imaging |
| url | http://actamedicaportuguesa.com/revista/index.php/amp/article/view/8712 |
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