Echinacoside: A promising active natural products and pharmacological agents
Echinacoside, a natural phenylethanoid glycoside, was discovered and isolated from the garden plant Echinacea angustifolia DC., belonging to the Compositae family, approximately sixty years ago. Extensive investigations have revealed that it possesses a wide array of pharmacologically beneficial act...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661823003079 |
| _version_ | 1797582914112716800 |
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| author | Wang Wang Shujun Jiang Yang Zhao Guoxue Zhu |
| author_facet | Wang Wang Shujun Jiang Yang Zhao Guoxue Zhu |
| author_sort | Wang Wang |
| collection | DOAJ |
| description | Echinacoside, a natural phenylethanoid glycoside, was discovered and isolated from the garden plant Echinacea angustifolia DC., belonging to the Compositae family, approximately sixty years ago. Extensive investigations have revealed that it possesses a wide array of pharmacologically beneficial activities for human health, particularly notable for its neuroprotective and anticancer activity. Several crucial concerns surfaced, encompassing the recognition of active metabolites that exhibited inadequate bioavailability in their prototype form, the establishment of precise molecular signal pathways or targets associated with the aforementioned effects of echinacoside, and the scarcity of dependable clinical trials. Hence, the question remains unanswered as to whether scientific research can effectively utilize this natural compound. To support future studies on this natural product, it is imperative to provide a systematic overview and insights into potential future prospects. The current review provides a comprehensive analysis of the existing knowledge on echinacoside, encompassing its wide distribution, structural diversity and metabolism, diverse therapeutic applications, and improvement of echinacoside bioavailability for its potential utilization. |
| first_indexed | 2024-03-10T23:29:20Z |
| format | Article |
| id | doaj.art-09b826bd230b41adaffa8073e3fd71b7 |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-10T23:29:20Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-09b826bd230b41adaffa8073e3fd71b72023-11-19T04:34:16ZengElsevierPharmacological Research1096-11862023-11-01197106951Echinacoside: A promising active natural products and pharmacological agentsWang Wang0Shujun Jiang1Yang Zhao2Guoxue Zhu3Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China; School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China; Corresponding authors.Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China; Corresponding authors.Echinacoside, a natural phenylethanoid glycoside, was discovered and isolated from the garden plant Echinacea angustifolia DC., belonging to the Compositae family, approximately sixty years ago. Extensive investigations have revealed that it possesses a wide array of pharmacologically beneficial activities for human health, particularly notable for its neuroprotective and anticancer activity. Several crucial concerns surfaced, encompassing the recognition of active metabolites that exhibited inadequate bioavailability in their prototype form, the establishment of precise molecular signal pathways or targets associated with the aforementioned effects of echinacoside, and the scarcity of dependable clinical trials. Hence, the question remains unanswered as to whether scientific research can effectively utilize this natural compound. To support future studies on this natural product, it is imperative to provide a systematic overview and insights into potential future prospects. The current review provides a comprehensive analysis of the existing knowledge on echinacoside, encompassing its wide distribution, structural diversity and metabolism, diverse therapeutic applications, and improvement of echinacoside bioavailability for its potential utilization.http://www.sciencedirect.com/science/article/pii/S1043661823003079EchinacosideSource and metabolismBiological activitiesPharmaceutical applicationsBioavailability |
| spellingShingle | Wang Wang Shujun Jiang Yang Zhao Guoxue Zhu Echinacoside: A promising active natural products and pharmacological agents Pharmacological Research Echinacoside Source and metabolism Biological activities Pharmaceutical applications Bioavailability |
| title | Echinacoside: A promising active natural products and pharmacological agents |
| title_full | Echinacoside: A promising active natural products and pharmacological agents |
| title_fullStr | Echinacoside: A promising active natural products and pharmacological agents |
| title_full_unstemmed | Echinacoside: A promising active natural products and pharmacological agents |
| title_short | Echinacoside: A promising active natural products and pharmacological agents |
| title_sort | echinacoside a promising active natural products and pharmacological agents |
| topic | Echinacoside Source and metabolism Biological activities Pharmaceutical applications Bioavailability |
| url | http://www.sciencedirect.com/science/article/pii/S1043661823003079 |
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