Death-associated protein 3 in cancer—discrepant roles of DAP3 in tumours and molecular mechanisms
Cancer, ranks as the secondary cause of death, is a group of diseases that are characterized by uncontrolled tumor growth and distant metastasis, leading to increased mortality year-on-year. To date, targeted therapy to intercept the aberrant proliferation and invasion is crucial for clinical antica...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1323751/full |
| _version_ | 1797338658911551488 |
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| author | Hao Song Hao Song Huifang Liu Huifang Liu Xiufeng Wang Yuteng Yang Yuteng Yang Xiangkun Zhao Xiangkun Zhao Wen G. Jiang Laijian Sui Xicheng Song |
| author_facet | Hao Song Hao Song Huifang Liu Huifang Liu Xiufeng Wang Yuteng Yang Yuteng Yang Xiangkun Zhao Xiangkun Zhao Wen G. Jiang Laijian Sui Xicheng Song |
| author_sort | Hao Song |
| collection | DOAJ |
| description | Cancer, ranks as the secondary cause of death, is a group of diseases that are characterized by uncontrolled tumor growth and distant metastasis, leading to increased mortality year-on-year. To date, targeted therapy to intercept the aberrant proliferation and invasion is crucial for clinical anticancer treatment, however, mutant expression of target genes often leads to drug resistance. Therefore, it is essential to identify more molecules that can be targeted to facilitate combined therapy. Previous studies showed that death associated protein 3 (DAP3) exerts a pivotal role in regulating apoptosis signaling of tumors, meanwhile, aberrant DAP3 expression is associated with the tumorigenesis and disease progression of various cancers. This review provides an overview of the molecule structure of DAP3 and the discrepant roles played by DAP3 in various types of tumors. Considering the molecular mechanism of DAP3-regulated cancer development, new potential treatment strategies might be developed in the future. |
| first_indexed | 2024-03-08T09:34:29Z |
| format | Article |
| id | doaj.art-09b89c697f6e40a6b0779635416f6175 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T09:34:29Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-09b89c697f6e40a6b0779635416f61752024-01-30T11:52:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011310.3389/fonc.2023.13237511323751Death-associated protein 3 in cancer—discrepant roles of DAP3 in tumours and molecular mechanismsHao Song0Hao Song1Huifang Liu2Huifang Liu3Xiufeng Wang4Yuteng Yang5Yuteng Yang6Xiangkun Zhao7Xiangkun Zhao8Wen G. Jiang9Laijian Sui10Xicheng Song11The Second Medical College, Binzhou Medical University, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaThe Second Medical College, Binzhou Medical University, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaDepartment of Nursing, Zhaoyuan People's Hospital, Yantai, ChinaThe Second Medical College, Binzhou Medical University, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaThe Second Medical College, Binzhou Medical University, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaCardiff China Medical Research Collaborative, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, United KingdomDepartment of Orthopedics, Yantai Yuhuangding Hospital of Qingdao University, Yantai, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, ChinaCancer, ranks as the secondary cause of death, is a group of diseases that are characterized by uncontrolled tumor growth and distant metastasis, leading to increased mortality year-on-year. To date, targeted therapy to intercept the aberrant proliferation and invasion is crucial for clinical anticancer treatment, however, mutant expression of target genes often leads to drug resistance. Therefore, it is essential to identify more molecules that can be targeted to facilitate combined therapy. Previous studies showed that death associated protein 3 (DAP3) exerts a pivotal role in regulating apoptosis signaling of tumors, meanwhile, aberrant DAP3 expression is associated with the tumorigenesis and disease progression of various cancers. This review provides an overview of the molecule structure of DAP3 and the discrepant roles played by DAP3 in various types of tumors. Considering the molecular mechanism of DAP3-regulated cancer development, new potential treatment strategies might be developed in the future.https://www.frontiersin.org/articles/10.3389/fonc.2023.1323751/fullDAP3cancerapoptosismolecular signalingtumor progression |
| spellingShingle | Hao Song Hao Song Huifang Liu Huifang Liu Xiufeng Wang Yuteng Yang Yuteng Yang Xiangkun Zhao Xiangkun Zhao Wen G. Jiang Laijian Sui Xicheng Song Death-associated protein 3 in cancer—discrepant roles of DAP3 in tumours and molecular mechanisms Frontiers in Oncology DAP3 cancer apoptosis molecular signaling tumor progression |
| title | Death-associated protein 3 in cancer—discrepant roles of DAP3 in tumours and molecular mechanisms |
| title_full | Death-associated protein 3 in cancer—discrepant roles of DAP3 in tumours and molecular mechanisms |
| title_fullStr | Death-associated protein 3 in cancer—discrepant roles of DAP3 in tumours and molecular mechanisms |
| title_full_unstemmed | Death-associated protein 3 in cancer—discrepant roles of DAP3 in tumours and molecular mechanisms |
| title_short | Death-associated protein 3 in cancer—discrepant roles of DAP3 in tumours and molecular mechanisms |
| title_sort | death associated protein 3 in cancer discrepant roles of dap3 in tumours and molecular mechanisms |
| topic | DAP3 cancer apoptosis molecular signaling tumor progression |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1323751/full |
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