Tetrahydropalmatine: Orchestrating survival – Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps

Tetrahydropalmatine: Orchestrating survival – Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps

Background: Introduced in clinical practice in 1989, perforator flaps are vital for tissue defect repair, but they are challenged by distal necrosis. Tetrahydropalmatine (THP) from celandine is renowned for its anti-inflammatory and analgesic effects. This study investigates THP's use in perfor...

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Bibliographic Details
Main Authors: Xuankuai Chen, Kejian Fu, Yingying Lai, Chengji Dong, Zhuliu Chen, Yingying Huang, Guangyao Li, Renhao Jiang, Hongqiang Wu, Anyuan Wang, Shaojie Huang, Liyan Shen, Weiyang Gao, Shi Li
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Multi-territory perforator flap
Tetrahydropalmatine
Angiogenesis
Autophagy
Apoptosis
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223016852

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