Mycobacterial protein PE_PGRS30 induces macrophage apoptosis through prohibitin 2 mitochondrial function interference

Mycobacterial protein PE_PGRS30 induces macrophage apoptosis through prohibitin 2 mitochondrial function interference

PE_PGRS30 belongs to the PE_PGRS protein family and is characterized by a conserved Pro-Glu (PE) domain and a typically polymorphic GC-rich sequence (PGRS) domain. PE_PGRS30 is a virulence factor of Mycobacterium tuberculosis that induces macrophage cell death. We found that RAW264.7 cells and murin...

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Bibliographic Details
Main Authors: Kazunori Matsumura, Satoshi Takaki, Teruo Kirikae
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
PE_PGRS30
PHB2
tuberculosis
macrophages
apoptosis
mitochondria
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1080369/full

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