Targeting Striatal Glutamate and Phosphodiesterases to Control L-DOPA-Induced Dyskinesia

Targeting Striatal Glutamate and Phosphodiesterases to Control L-DOPA-Induced Dyskinesia

A large body of work during the past several decades has been focused on therapeutic strategies to control L-DOPA-induced dyskinesias (LIDs), common motor complications of long-term L-DOPA therapy in Parkinson’s disease (PD). Yet, LIDs remain a clinical challenge for the management of patients with...

Full description

Bibliographic Details
Main Authors: Brik A. Kochoian, Cassandra Bure, Stella M. Papa
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
L-DOPA-induced dyskinesia
Parkinson’s disease
glutamate
phosphodiesterase
striatal projection neuron
NMDAR
Online Access:https://www.mdpi.com/2073-4409/12/23/2754

Similar Items

Similar Items