Association of Pain Phenotypes with Risk of Falls and Incident Fractures
<b>Objective:</b> To compare whether falls risk score and incident fracture over 10.7 years were different among three previously identified pain phenotypes. <b>Methods:</b> Data on 915 participants (mean age 63 years) from a population-based cohort study were studied at base...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/11/2924 |
| _version_ | 1827644896085803008 |
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| author | Maxim Devine Canchen Ma Jing Tian Benny Antony Flavia Cicuttini Graeme Jones Feng Pan |
| author_facet | Maxim Devine Canchen Ma Jing Tian Benny Antony Flavia Cicuttini Graeme Jones Feng Pan |
| author_sort | Maxim Devine |
| collection | DOAJ |
| description | <b>Objective:</b> To compare whether falls risk score and incident fracture over 10.7 years were different among three previously identified pain phenotypes. <b>Methods:</b> Data on 915 participants (mean age 63 years) from a population-based cohort study were studied at baseline and follow-ups at 2.6, 5.1 and 10.7 years. Three pain phenotypes were previously identified using the latent class analysis: Class 1: high prevalence of emotional problems and low prevalence of structural damage; Class 2: high prevalence of structural damage and low prevalence of emotional problems; Class 3: low prevalence of emotional problems and low prevalence of structural damage. Fractures were self-reported and falls risk score was measured using the Physiological Profile Assessment. Generalized estimating equations model and linear mixed-effects model were used to compare differences in incident fractures and falls risk score over 10.7 years between pain phenotypes, respectively. <b>Results:</b> There were 3 new hip, 19 vertebral, and 121 non-vertebral fractures, and 138 any site fractures during 10.7-year follow-up. Compared with Class 3, Class 1 had a higher risk of vertebral (relative risk (RR) = 2.44, 95% CI: 1.22–4.91), non-vertebral fractures (RR = 1.20, 95% CI: 1.01–1.42), and any site fractures (RR = 1.24, 95% CI: 1.04–1.46) after controlling for covariates, bone mineral density and falls risk score. Class 2 had a higher risk of non-vertebral and any site fracture relative to those in Class 3 (non-vertebral: RR = 1.41, 95% CI: 1.17–1.71; any site: RR = 1.44, 95% CI: 1.20–1.73), but not vertebral fracture. Compared with Class 3, Class 1 had a higher falls risk score at baseline (β = 0.16, 95% CI: 0.09–0.23) and over 10.7-year (β = 0.03, 95% CI: 0.01–0.04). <b>Conclusions:</b> Class 1 and/or Class 2 had a higher risk of incident fractures and falls risk score than Class 3, highlighting that targeted preventive strategies for fractures and falls are needed in pain population. |
| first_indexed | 2024-03-09T18:27:00Z |
| format | Article |
| id | doaj.art-09c661c600394f9881f4c68410d95844 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T18:27:00Z |
| publishDate | 2022-11-01 |
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| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-09c661c600394f9881f4c68410d958442023-11-24T07:46:14ZengMDPI AGBiomedicines2227-90592022-11-011011292410.3390/biomedicines10112924Association of Pain Phenotypes with Risk of Falls and Incident FracturesMaxim Devine0Canchen Ma1Jing Tian2Benny Antony3Flavia Cicuttini4Graeme Jones5Feng Pan6Menzies Institute for Medical Research, University of Tasmania, Hobart 7000, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart 7000, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart 7000, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart 7000, AustraliaDepartment of Epidemiology and Preventive Medicine, Monash University Medical School, Commercial Road, Melbourne 3181, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart 7000, AustraliaMenzies Institute for Medical Research, University of Tasmania, Hobart 7000, Australia<b>Objective:</b> To compare whether falls risk score and incident fracture over 10.7 years were different among three previously identified pain phenotypes. <b>Methods:</b> Data on 915 participants (mean age 63 years) from a population-based cohort study were studied at baseline and follow-ups at 2.6, 5.1 and 10.7 years. Three pain phenotypes were previously identified using the latent class analysis: Class 1: high prevalence of emotional problems and low prevalence of structural damage; Class 2: high prevalence of structural damage and low prevalence of emotional problems; Class 3: low prevalence of emotional problems and low prevalence of structural damage. Fractures were self-reported and falls risk score was measured using the Physiological Profile Assessment. Generalized estimating equations model and linear mixed-effects model were used to compare differences in incident fractures and falls risk score over 10.7 years between pain phenotypes, respectively. <b>Results:</b> There were 3 new hip, 19 vertebral, and 121 non-vertebral fractures, and 138 any site fractures during 10.7-year follow-up. Compared with Class 3, Class 1 had a higher risk of vertebral (relative risk (RR) = 2.44, 95% CI: 1.22–4.91), non-vertebral fractures (RR = 1.20, 95% CI: 1.01–1.42), and any site fractures (RR = 1.24, 95% CI: 1.04–1.46) after controlling for covariates, bone mineral density and falls risk score. Class 2 had a higher risk of non-vertebral and any site fracture relative to those in Class 3 (non-vertebral: RR = 1.41, 95% CI: 1.17–1.71; any site: RR = 1.44, 95% CI: 1.20–1.73), but not vertebral fracture. Compared with Class 3, Class 1 had a higher falls risk score at baseline (β = 0.16, 95% CI: 0.09–0.23) and over 10.7-year (β = 0.03, 95% CI: 0.01–0.04). <b>Conclusions:</b> Class 1 and/or Class 2 had a higher risk of incident fractures and falls risk score than Class 3, highlighting that targeted preventive strategies for fractures and falls are needed in pain population.https://www.mdpi.com/2227-9059/10/11/2924falls riskincident fracturespain phenotypes |
| spellingShingle | Maxim Devine Canchen Ma Jing Tian Benny Antony Flavia Cicuttini Graeme Jones Feng Pan Association of Pain Phenotypes with Risk of Falls and Incident Fractures Biomedicines falls risk incident fractures pain phenotypes |
| title | Association of Pain Phenotypes with Risk of Falls and Incident Fractures |
| title_full | Association of Pain Phenotypes with Risk of Falls and Incident Fractures |
| title_fullStr | Association of Pain Phenotypes with Risk of Falls and Incident Fractures |
| title_full_unstemmed | Association of Pain Phenotypes with Risk of Falls and Incident Fractures |
| title_short | Association of Pain Phenotypes with Risk of Falls and Incident Fractures |
| title_sort | association of pain phenotypes with risk of falls and incident fractures |
| topic | falls risk incident fractures pain phenotypes |
| url | https://www.mdpi.com/2227-9059/10/11/2924 |
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