Microfluidic Microcirculation Mimetic as a Tool for the Study of Rheological Characteristics of Red Blood Cells in Patients with Sickle Cell Anemia

Microfluidic Microcirculation Mimetic as a Tool for the Study of Rheological Characteristics of Red Blood Cells in Patients with Sickle Cell Anemia

Sickle cell disorder (SCD) is a multisystem disease with heterogeneous phenotypes. Although all patients have the mutated hemoglobin (Hb) in the SS phenotype, the severity and frequency of complications are variable. When exposed to low oxygen tension, the Hb molecule becomes dense and forms tactoid...

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Bibliographic Details
Main Authors: Marcus Inyama Asuquo, Emmanuel Effa, Oluwabukola Gbotosho, Akaninyene Otu, Nicole Toepfner, Soter Ameh, Sruti-Prathivadhi Bhayankaram, Noah Zetocha, Chisom Nwakama, William Egbe, Jochen Guck, Andrew Ekpenyong
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Applied Sciences
Subjects:
sickle cell disorder
vaso-occlusive crisis
hydroxyurea
microcirculation
microfluidics
personalized medicine
Online Access:https://www.mdpi.com/2076-3417/12/9/4394

Internet

https://www.mdpi.com/2076-3417/12/9/4394

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