Management of Skin Lesions in Patients with Epidermolysis Bullosa by Topical Treatment: Systematic Review and Meta-Analysis
Epidermolysis bullosa (EB) is the overarching term for a set of rare inherited skin fragility disorders that result from mutations in at least 20 different genes. Currently, there is no cure for any of the EB subtypes associated with various mutations. Existing therapies primarily focus on alleviati...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/12/2/261 |
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| author | Manuel Pabón-Carrasco Rocio Caceres-Matos Marta Roche-Campos Maria Antonia Hurtado-Guapo Mercedes Ortiz-Romero Luis M. Gordillo-Fernández Daniel Pabón-Carrasco Aurora Castro-Méndez |
| author_facet | Manuel Pabón-Carrasco Rocio Caceres-Matos Marta Roche-Campos Maria Antonia Hurtado-Guapo Mercedes Ortiz-Romero Luis M. Gordillo-Fernández Daniel Pabón-Carrasco Aurora Castro-Méndez |
| author_sort | Manuel Pabón-Carrasco |
| collection | DOAJ |
| description | Epidermolysis bullosa (EB) is the overarching term for a set of rare inherited skin fragility disorders that result from mutations in at least 20 different genes. Currently, there is no cure for any of the EB subtypes associated with various mutations. Existing therapies primarily focus on alleviating pain and promoting early wound healing to prevent potential complications. Consequently, there is an urgent need for innovative therapeutic approaches. The objective of this research was to assess the efficacy of various topical treatments in patients with EB with the goal of achieving wound healing. A secondary objective was to analyse the efficacy of topical treatments for symptom reduction. A literature search was conducted using scientific databases, including The Cochrane Library, Medline (Pubmed), Web of Science, CINHAL, Embase, and Scopus. The protocol review was registered in PROSPERO (ID: 418790), and inclusion and exclusion criteria were applied, resulting in the selection of 23 articles. Enhanced healing times were observed compared with the control group. No conclusive data have been observed on pain management, infection, pruritus episodes, and cure rates over time. Additionally, evidence indicates significant progress in gene therapies (B-VEC), as well as cell and protein therapies. The dressing group, Oleogel S-10, allantoin and diacerein 1%, were the most represented, followed by fibroblast utilisation. In addition, emerging treatments that improve the patient’s innate immunity, such as calcipotriol, are gaining attention. However, more trials are needed to reduce the prevalence of blistering and improve the quality of life of individuals with epidermolysis bullosa. |
| first_indexed | 2024-03-08T10:49:58Z |
| format | Article |
| id | doaj.art-09ca7ec5d5464a0eaad11cecc085754a |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-08T10:49:58Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-09ca7ec5d5464a0eaad11cecc085754a2024-01-26T16:48:14ZengMDPI AGHealthcare2227-90322024-01-0112226110.3390/healthcare12020261Management of Skin Lesions in Patients with Epidermolysis Bullosa by Topical Treatment: Systematic Review and Meta-AnalysisManuel Pabón-Carrasco0Rocio Caceres-Matos1Marta Roche-Campos2Maria Antonia Hurtado-Guapo3Mercedes Ortiz-Romero4Luis M. Gordillo-Fernández5Daniel Pabón-Carrasco6Aurora Castro-Méndez7Research Group PAIDI-CTS-1054: “Interventions and Health Care, Red Cross (ICSCRE)”, Nursing Department, Faculty of Nursing, Physiotherapy and Podiatry, University of Seville, 6 Avenzoar ST, 41009 Seville, SpainResearch Group PAIDI-CTS-1050: “Complex Care, Chronicity and Health Outcomes”, Nursing Department, Faculty of Nursing, Physiotherapy and Podiatry, University of Seville, 6 Avenzoar ST, 41009 Seville, SpainHospital Universitario de Cruce, 48903 Bilbao, SpainNursing Department, Faculty of Nursing, Extremadura University, 06006 Badajoz, SpainFaculty of Nursing, Physiotherapy and Podiatry, University of Seville, 41009 Seville, SpainFaculty of Nursing, Physiotherapy and Podiatry, University of Seville, 41009 Seville, SpainCrux Roxa Rehabilitación, 41008 Sevilla, SpainFaculty of Nursing, Physiotherapy and Podiatry, University of Seville, 41009 Seville, SpainEpidermolysis bullosa (EB) is the overarching term for a set of rare inherited skin fragility disorders that result from mutations in at least 20 different genes. Currently, there is no cure for any of the EB subtypes associated with various mutations. Existing therapies primarily focus on alleviating pain and promoting early wound healing to prevent potential complications. Consequently, there is an urgent need for innovative therapeutic approaches. The objective of this research was to assess the efficacy of various topical treatments in patients with EB with the goal of achieving wound healing. A secondary objective was to analyse the efficacy of topical treatments for symptom reduction. A literature search was conducted using scientific databases, including The Cochrane Library, Medline (Pubmed), Web of Science, CINHAL, Embase, and Scopus. The protocol review was registered in PROSPERO (ID: 418790), and inclusion and exclusion criteria were applied, resulting in the selection of 23 articles. Enhanced healing times were observed compared with the control group. No conclusive data have been observed on pain management, infection, pruritus episodes, and cure rates over time. Additionally, evidence indicates significant progress in gene therapies (B-VEC), as well as cell and protein therapies. The dressing group, Oleogel S-10, allantoin and diacerein 1%, were the most represented, followed by fibroblast utilisation. In addition, emerging treatments that improve the patient’s innate immunity, such as calcipotriol, are gaining attention. However, more trials are needed to reduce the prevalence of blistering and improve the quality of life of individuals with epidermolysis bullosa.https://www.mdpi.com/2227-9032/12/2/261epidermolysis bullosalesions bulloustopical administrationreview systematicmeta-analysis |
| spellingShingle | Manuel Pabón-Carrasco Rocio Caceres-Matos Marta Roche-Campos Maria Antonia Hurtado-Guapo Mercedes Ortiz-Romero Luis M. Gordillo-Fernández Daniel Pabón-Carrasco Aurora Castro-Méndez Management of Skin Lesions in Patients with Epidermolysis Bullosa by Topical Treatment: Systematic Review and Meta-Analysis Healthcare epidermolysis bullosa lesions bullous topical administration review systematic meta-analysis |
| title | Management of Skin Lesions in Patients with Epidermolysis Bullosa by Topical Treatment: Systematic Review and Meta-Analysis |
| title_full | Management of Skin Lesions in Patients with Epidermolysis Bullosa by Topical Treatment: Systematic Review and Meta-Analysis |
| title_fullStr | Management of Skin Lesions in Patients with Epidermolysis Bullosa by Topical Treatment: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Management of Skin Lesions in Patients with Epidermolysis Bullosa by Topical Treatment: Systematic Review and Meta-Analysis |
| title_short | Management of Skin Lesions in Patients with Epidermolysis Bullosa by Topical Treatment: Systematic Review and Meta-Analysis |
| title_sort | management of skin lesions in patients with epidermolysis bullosa by topical treatment systematic review and meta analysis |
| topic | epidermolysis bullosa lesions bullous topical administration review systematic meta-analysis |
| url | https://www.mdpi.com/2227-9032/12/2/261 |
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