The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones
The antibacterial and antifungal activity against gram-positive and gram-negative bacteria and Candida albicans fungal strain for alkyltetrahydroisoquinoline derivatives were evaluated. It was established, that 1,11-bis(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)undecan shows pronounced antiba...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taras Shevchenko National University of Kyiv
2018-03-01
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| Series: | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
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| Online Access: | http://biovestnik.com/index.php/biology/article/view/291 |
| _version_ | 1827886726065946624 |
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| author | E. Terenteva S. Sasmakov S. Azimov V. Vinogradova D. Abdurakhmanov Z. Khashimova A. Saidov |
| author_facet | E. Terenteva S. Sasmakov S. Azimov V. Vinogradova D. Abdurakhmanov Z. Khashimova A. Saidov |
| author_sort | E. Terenteva |
| collection | DOAJ |
| description | The antibacterial and antifungal activity against gram-positive and gram-negative bacteria and Candida albicans fungal strain for alkyltetrahydroisoquinoline
derivatives were evaluated. It was established, that 1,11-bis(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)undecan shows pronounced antibacterial properties against all the microorganism strains and strong antifungal activity against Candida albicans with greater inhibition area than the reference drug. IC50 value of the compound is 2,1±0,1 μg/ml, LD50 value is 324,9±18,2 mg/kg. |
| first_indexed | 2024-03-12T20:07:33Z |
| format | Article |
| id | doaj.art-09cb4bb535e848d3b7a6ab6ed8d0db66 |
| institution | Directory Open Access Journal |
| issn | 1728-2748 2308-8036 |
| language | English |
| last_indexed | 2024-03-12T20:07:33Z |
| publishDate | 2018-03-01 |
| publisher | Taras Shevchenko National University of Kyiv |
| record_format | Article |
| series | Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ |
| spelling | doaj.art-09cb4bb535e848d3b7a6ab6ed8d0db662023-08-02T01:57:02ZengTaras Shevchenko National University of KyivVìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ1728-27482308-80362018-03-01742515510.17721/1728_2748.2017.74.51-55198The antimicrobial activity and toxicity od alkyltetrahydroisoquinolonesE. Terenteva0S. Sasmakov1S. Azimov2V. Vinogradova3D. Abdurakhmanov4Z. Khashimova5A. Saidov6Institute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, TashkentInstitute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, TashkentInstitute of the Chemistry of Plant Substances, Uzbek Academy of Sciences, TashkentInstitute of the Chemistry of Plant Substances, Uzbek Academy of SciencesInstitute of the Chemistry of Plant Substances, Uzbek Academy of SciencesInstitute of the Bioorganic Chemistry, Uzbek Academy of Sciences,TashkentSamarkand State University, SamarkandThe antibacterial and antifungal activity against gram-positive and gram-negative bacteria and Candida albicans fungal strain for alkyltetrahydroisoquinoline derivatives were evaluated. It was established, that 1,11-bis(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)undecan shows pronounced antibacterial properties against all the microorganism strains and strong antifungal activity against Candida albicans with greater inhibition area than the reference drug. IC50 value of the compound is 2,1±0,1 μg/ml, LD50 value is 324,9±18,2 mg/kg.http://biovestnik.com/index.php/biology/article/view/291alkyltetrahydroisoquinolines, IC50, LD50, the antimicrobial activity, toxicity. |
| spellingShingle | E. Terenteva S. Sasmakov S. Azimov V. Vinogradova D. Abdurakhmanov Z. Khashimova A. Saidov The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones Vìsnik: Kiïvsʹkij Nacìonalʹnij Unìversitet Imenì Tarasa Ševčenka. Bìologìâ alkyltetrahydroisoquinolines, IC50, LD50, the antimicrobial activity, toxicity. |
| title | The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones |
| title_full | The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones |
| title_fullStr | The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones |
| title_full_unstemmed | The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones |
| title_short | The antimicrobial activity and toxicity od alkyltetrahydroisoquinolones |
| title_sort | antimicrobial activity and toxicity od alkyltetrahydroisoquinolones |
| topic | alkyltetrahydroisoquinolines, IC50, LD50, the antimicrobial activity, toxicity. |
| url | http://biovestnik.com/index.php/biology/article/view/291 |
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