3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing

Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms. However, 3D printing techniques differ greatly in terms...

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Main Authors: Nadine Gottschalk, Malte Bogdahn, Julian Quodbach
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156723000233
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author Nadine Gottschalk
Malte Bogdahn
Julian Quodbach
author_facet Nadine Gottschalk
Malte Bogdahn
Julian Quodbach
author_sort Nadine Gottschalk
collection DOAJ
description Nowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms. However, 3D printing techniques differ greatly in terms of processing as well as tablet properties. In this study, an amorphous formulation, which had been printed via Fused Deposition Modeling and drop-on-powder printing, also known as binder jetting, was characterized in terms of solid-state properties and physical stability. Solid state assessment was performed by differential scanning calorimetry, powder X-ray diffraction and polarized microscopy. The supersaturation performance of the amorphous solid dispersion was assessed via non-sink dissolution. We further evaluated both 3D printing techniques regarding their processability as well as tablet uniformity in terms of dimension, mass and content. Challenges and limitations of each 3D printing technique were discussed. Both techniques are feasible for the production of amorphous formulations. Results indicated that Fused Deposition Modeling is better suited for production, as the recrystallization tendency was lower. Still, filament production and printing presented a major challenge. Drop-on-powder printing can be a viable alternative for the production of amorphous tablets, when a formulation is not printable by Fused Deposition Modeling.
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spelling doaj.art-09cd32e2a0544c71ac431438cb44475c2023-06-21T06:59:15ZengElsevierInternational Journal of Pharmaceutics: X2590-15672023-12-0151001793D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printingNadine Gottschalk0Malte Bogdahn1Julian Quodbach2Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Düsseldorf, Germany; Merck KGaA, Darmstadt, GermanyMerck KGaA, Darmstadt, Germany; Corresponding author.Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Düsseldorf, Germany; Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, NetherlandsNowadays, a high number of pipeline drugs are poorly soluble and require solubility enhancement by e.g., manufacturing of amorphous solid dispersion. Pharmaceutical 3D printing has great potential in producing amorphous solid oral dosage forms. However, 3D printing techniques differ greatly in terms of processing as well as tablet properties. In this study, an amorphous formulation, which had been printed via Fused Deposition Modeling and drop-on-powder printing, also known as binder jetting, was characterized in terms of solid-state properties and physical stability. Solid state assessment was performed by differential scanning calorimetry, powder X-ray diffraction and polarized microscopy. The supersaturation performance of the amorphous solid dispersion was assessed via non-sink dissolution. We further evaluated both 3D printing techniques regarding their processability as well as tablet uniformity in terms of dimension, mass and content. Challenges and limitations of each 3D printing technique were discussed. Both techniques are feasible for the production of amorphous formulations. Results indicated that Fused Deposition Modeling is better suited for production, as the recrystallization tendency was lower. Still, filament production and printing presented a major challenge. Drop-on-powder printing can be a viable alternative for the production of amorphous tablets, when a formulation is not printable by Fused Deposition Modeling.http://www.sciencedirect.com/science/article/pii/S2590156723000233Fused deposition modelingDrop-on-powderBinder jettingAmorphous solid dispersionSolubility enhancement3D printing
spellingShingle Nadine Gottschalk
Malte Bogdahn
Julian Quodbach
3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing
International Journal of Pharmaceutics: X
Fused deposition modeling
Drop-on-powder
Binder jetting
Amorphous solid dispersion
Solubility enhancement
3D printing
title 3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing
title_full 3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing
title_fullStr 3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing
title_full_unstemmed 3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing
title_short 3D printing of amorphous solid dispersions: A comparison of fused deposition modeling and drop-on-powder printing
title_sort 3d printing of amorphous solid dispersions a comparison of fused deposition modeling and drop on powder printing
topic Fused deposition modeling
Drop-on-powder
Binder jetting
Amorphous solid dispersion
Solubility enhancement
3D printing
url http://www.sciencedirect.com/science/article/pii/S2590156723000233
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AT julianquodbach 3dprintingofamorphoussoliddispersionsacomparisonoffuseddepositionmodelinganddroponpowderprinting