Six challenges in the eradication of infectious diseases
Eradication and elimination are increasingly a part of the global health agenda. Once control measures have driven infection to low levels, the ecology of disease may change posing challenges for eradication efforts. These challenges vary from identifying pockets of susceptibles, improving monitorin...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-03-01
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| Series: | Epidemics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175543651400070X |
| _version_ | 1818494073863929856 |
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| author | Petra Klepac Sebastian Funk T. Deirdre Hollingsworth C. Jessica E. Metcalf Katie Hampson |
| author_facet | Petra Klepac Sebastian Funk T. Deirdre Hollingsworth C. Jessica E. Metcalf Katie Hampson |
| author_sort | Petra Klepac |
| collection | DOAJ |
| description | Eradication and elimination are increasingly a part of the global health agenda. Once control measures have driven infection to low levels, the ecology of disease may change posing challenges for eradication efforts. These challenges vary from identifying pockets of susceptibles, improving monitoring during and after the endgame, to quantifying the economics of disease eradication versus sustained control, all of which are shaped and influenced by processes of loss of immunity, susceptible build-up, emergence of resistance, population heterogeneities and non-compliance with control measures. Here we discuss how modelling can be used to address these challenges. |
| first_indexed | 2024-12-10T18:01:54Z |
| format | Article |
| id | doaj.art-09cd491682cf4a099aa8358a565eb5e5 |
| institution | Directory Open Access Journal |
| issn | 1755-4365 1878-0067 |
| language | English |
| last_indexed | 2024-12-10T18:01:54Z |
| publishDate | 2015-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Epidemics |
| spelling | doaj.art-09cd491682cf4a099aa8358a565eb5e52022-12-22T01:38:44ZengElsevierEpidemics1755-43651878-00672015-03-0110C9710110.1016/j.epidem.2014.12.001Six challenges in the eradication of infectious diseasesPetra Klepac0Sebastian Funk1T. Deirdre Hollingsworth2C. Jessica E. Metcalf3Katie Hampson4Department of Applied Mathematics and Theoretical Physics, Cambridge University, Cambridge, UKCentre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UKMathematics Institute and the School of Life Sciences, University of Warwick, UKDepartment of Ecology and Evolutionary Biology and the Woodrow Wilson School, Princeton University, Princeton, NJ, USABoyd Orr Centre for Population and Ecosystem Health, University of Glasgow, UKEradication and elimination are increasingly a part of the global health agenda. Once control measures have driven infection to low levels, the ecology of disease may change posing challenges for eradication efforts. These challenges vary from identifying pockets of susceptibles, improving monitoring during and after the endgame, to quantifying the economics of disease eradication versus sustained control, all of which are shaped and influenced by processes of loss of immunity, susceptible build-up, emergence of resistance, population heterogeneities and non-compliance with control measures. Here we discuss how modelling can be used to address these challenges.http://www.sciencedirect.com/science/article/pii/S175543651400070XEliminationSurveillanceModellingDynamicsHeterogeneity |
| spellingShingle | Petra Klepac Sebastian Funk T. Deirdre Hollingsworth C. Jessica E. Metcalf Katie Hampson Six challenges in the eradication of infectious diseases Epidemics Elimination Surveillance Modelling Dynamics Heterogeneity |
| title | Six challenges in the eradication of infectious diseases |
| title_full | Six challenges in the eradication of infectious diseases |
| title_fullStr | Six challenges in the eradication of infectious diseases |
| title_full_unstemmed | Six challenges in the eradication of infectious diseases |
| title_short | Six challenges in the eradication of infectious diseases |
| title_sort | six challenges in the eradication of infectious diseases |
| topic | Elimination Surveillance Modelling Dynamics Heterogeneity |
| url | http://www.sciencedirect.com/science/article/pii/S175543651400070X |
| work_keys_str_mv | AT petraklepac sixchallengesintheeradicationofinfectiousdiseases AT sebastianfunk sixchallengesintheeradicationofinfectiousdiseases AT tdeirdrehollingsworth sixchallengesintheeradicationofinfectiousdiseases AT cjessicaemetcalf sixchallengesintheeradicationofinfectiousdiseases AT katiehampson sixchallengesintheeradicationofinfectiousdiseases |