Can Peri-Implant Marginal Bone Loss Progression and a-MMP-8 Be Considered Indicators of the Subsequent Onset of Peri-Implantitis? A 5-Year Study
The aim of this retrospective study was to investigate the relationship between the amount of early bone remodeling, the marginal bone loss (MBL) progression, and the peri-implant sulcular fluid concentration of active metalloproteinase-8 (a-MMP-8) and the incidence of peri-implantitis (P) over 5 ye...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/11/2599 |
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| author | Renzo Guarnieri Rodolfo Reda Alessio Zanza Gabriele Miccoli Dario Di Nardo Luca Testarelli |
| author_facet | Renzo Guarnieri Rodolfo Reda Alessio Zanza Gabriele Miccoli Dario Di Nardo Luca Testarelli |
| author_sort | Renzo Guarnieri |
| collection | DOAJ |
| description | The aim of this retrospective study was to investigate the relationship between the amount of early bone remodeling, the marginal bone loss (MBL) progression, and the peri-implant sulcular fluid concentration of active metalloproteinase-8 (a-MMP-8) and the incidence of peri-implantitis (P) over 5 years of implant function. It has been documented that dental implants with a high degree of early marginal bone loss (MBL) are likely to achieve additional increased MBL during function. Moreover, it has been speculated that early increased MBL might be a predictive factor for the subsequent onset of peri-implant inflammatory diseases. Clinical and radiographic data at implant placement (T0) and restoration delivery (TR) at 6 months (T1), 2 years (T2), and 5 years (T5) post-loading were retrospectively collected. MBL levels/rates (MBLr) and peri-implant sulcular fluid levels/rates of a-MMP-8 were assessed at TR, T1, T2, and T5. Implants were divided into two groups: group 1 with peri-implantitis (P+) and group 2 without peri-implantitis (P−). A multi-level simple binary logistic regression, using generalized estimation equations (GEEs), was implemented to assess the association between each independent variable and P+. A receiver operating characteristics (ROC) curve was used to evaluate an optimal cutoff point for T1 MBL degree and a-MMP-8 level to discriminate between P+ and P− implants. A total of 80 patients who had received 80 implants between them (39 implants with a laser-microtextured collar surface (LMS) and 41 implants with a machined collar surface (MS)) were included. Periapical radiographs and a software package were used to measure MBL rates. Peri-implant sulcular implant fluid samples were analyzed by a chairside mouth-rinse test (ImplantSafe<sup>®</sup>) in combination with a digital reader (ORALyzer<sup>®</sup>). Twenty-four implants (six with an LMS and eighteen with an MS) were classified as P+. No statistically significant association was found between the amount of early bone remodeling, MBL progression, and MBLr and the incidence of peri-implantitis. Implants with a-MMP-8 levels >15.3 ng/mL at T1 presented a significantly higher probability of P+. The amount of early marginal bone remodeling cannot be considered as an indicator of the subsequent onset of P, whereas high a-MMP-8 levels 6 months after loading could have a distinct ability to predict P. |
| first_indexed | 2024-03-09T19:08:59Z |
| format | Article |
| id | doaj.art-09cd5f2c967f4ed68c96513024241888 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:08:59Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj.art-09cd5f2c967f4ed68c965130242418882023-11-24T04:17:51ZengMDPI AGDiagnostics2075-44182022-10-011211259910.3390/diagnostics12112599Can Peri-Implant Marginal Bone Loss Progression and a-MMP-8 Be Considered Indicators of the Subsequent Onset of Peri-Implantitis? A 5-Year StudyRenzo Guarnieri0Rodolfo Reda1Alessio Zanza2Gabriele Miccoli3Dario Di Nardo4Luca Testarelli5Private Periodontal Implant Practice, 31100 Treviso, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, ItalyThe aim of this retrospective study was to investigate the relationship between the amount of early bone remodeling, the marginal bone loss (MBL) progression, and the peri-implant sulcular fluid concentration of active metalloproteinase-8 (a-MMP-8) and the incidence of peri-implantitis (P) over 5 years of implant function. It has been documented that dental implants with a high degree of early marginal bone loss (MBL) are likely to achieve additional increased MBL during function. Moreover, it has been speculated that early increased MBL might be a predictive factor for the subsequent onset of peri-implant inflammatory diseases. Clinical and radiographic data at implant placement (T0) and restoration delivery (TR) at 6 months (T1), 2 years (T2), and 5 years (T5) post-loading were retrospectively collected. MBL levels/rates (MBLr) and peri-implant sulcular fluid levels/rates of a-MMP-8 were assessed at TR, T1, T2, and T5. Implants were divided into two groups: group 1 with peri-implantitis (P+) and group 2 without peri-implantitis (P−). A multi-level simple binary logistic regression, using generalized estimation equations (GEEs), was implemented to assess the association between each independent variable and P+. A receiver operating characteristics (ROC) curve was used to evaluate an optimal cutoff point for T1 MBL degree and a-MMP-8 level to discriminate between P+ and P− implants. A total of 80 patients who had received 80 implants between them (39 implants with a laser-microtextured collar surface (LMS) and 41 implants with a machined collar surface (MS)) were included. Periapical radiographs and a software package were used to measure MBL rates. Peri-implant sulcular implant fluid samples were analyzed by a chairside mouth-rinse test (ImplantSafe<sup>®</sup>) in combination with a digital reader (ORALyzer<sup>®</sup>). Twenty-four implants (six with an LMS and eighteen with an MS) were classified as P+. No statistically significant association was found between the amount of early bone remodeling, MBL progression, and MBLr and the incidence of peri-implantitis. Implants with a-MMP-8 levels >15.3 ng/mL at T1 presented a significantly higher probability of P+. The amount of early marginal bone remodeling cannot be considered as an indicator of the subsequent onset of P, whereas high a-MMP-8 levels 6 months after loading could have a distinct ability to predict P.https://www.mdpi.com/2075-4418/12/11/2599implantMMP-8marginal bone lossperi-implant sulcusinterleukins |
| spellingShingle | Renzo Guarnieri Rodolfo Reda Alessio Zanza Gabriele Miccoli Dario Di Nardo Luca Testarelli Can Peri-Implant Marginal Bone Loss Progression and a-MMP-8 Be Considered Indicators of the Subsequent Onset of Peri-Implantitis? A 5-Year Study Diagnostics implant MMP-8 marginal bone loss peri-implant sulcus interleukins |
| title | Can Peri-Implant Marginal Bone Loss Progression and a-MMP-8 Be Considered Indicators of the Subsequent Onset of Peri-Implantitis? A 5-Year Study |
| title_full | Can Peri-Implant Marginal Bone Loss Progression and a-MMP-8 Be Considered Indicators of the Subsequent Onset of Peri-Implantitis? A 5-Year Study |
| title_fullStr | Can Peri-Implant Marginal Bone Loss Progression and a-MMP-8 Be Considered Indicators of the Subsequent Onset of Peri-Implantitis? A 5-Year Study |
| title_full_unstemmed | Can Peri-Implant Marginal Bone Loss Progression and a-MMP-8 Be Considered Indicators of the Subsequent Onset of Peri-Implantitis? A 5-Year Study |
| title_short | Can Peri-Implant Marginal Bone Loss Progression and a-MMP-8 Be Considered Indicators of the Subsequent Onset of Peri-Implantitis? A 5-Year Study |
| title_sort | can peri implant marginal bone loss progression and a mmp 8 be considered indicators of the subsequent onset of peri implantitis a 5 year study |
| topic | implant MMP-8 marginal bone loss peri-implant sulcus interleukins |
| url | https://www.mdpi.com/2075-4418/12/11/2599 |
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