INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTS
In the retrospective multicenter study during 2007–2017 we included 59 oncohematological patients with mucormycosis and 541 patients with invasive aspergillosis. Our study showed that mucomorhycosis more often developed in children and adolescents (p = 0.001), and after «graft versus host» disease d...
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2018-07-01
|
| Series: | Онкогематология |
| Subjects: | |
| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/287 |
| _version_ | 1797855517417144320 |
|---|---|
| author | O. V. Shadrivova S. N. Khostelidi Y. A. Chudinovskikh V. S. Zabirov Y. V. Borzova E. A. Desyatik A. G. Volkova M. O. Popova I. V. Markova O. S. Uspenskaya O. S. Ruzhinskaya T. V. Shneyder T. S. Bogomolova S. M. Ignatyeva L. S. Zubarovskaya B. V. Afanasyev N. N. Klimko |
| author_facet | O. V. Shadrivova S. N. Khostelidi Y. A. Chudinovskikh V. S. Zabirov Y. V. Borzova E. A. Desyatik A. G. Volkova M. O. Popova I. V. Markova O. S. Uspenskaya O. S. Ruzhinskaya T. V. Shneyder T. S. Bogomolova S. M. Ignatyeva L. S. Zubarovskaya B. V. Afanasyev N. N. Klimko |
| author_sort | O. V. Shadrivova |
| collection | DOAJ |
| description | In the retrospective multicenter study during 2007–2017 we included 59 oncohematological patients with mucormycosis and 541 patients with invasive aspergillosis. Our study showed that mucomorhycosis more often developed in children and adolescents (p = 0.001), and after «graft versus host» disease development (p = 0.0001). Patients with mucormycosis were more immunosuppressed: severe neutropenia was in 88 % vs. 82 %, median duration of neutropenia ‒ 30 days vs. 14 days, p = 0.0001, lymphocytopenia – 77 % vs. 65 %, median duration of lymphocytopenia – 25 days vs. 14 days, p = 0.001. The main sites of infection were lungs, nevertheless in patients with mucormycosis it was less frequent (73 % vs. 97 %, p = 0.02), but more frequent were ≥2 organs involvement (42 % vs. 8 %, p = 0.001) and paranasal sinuses involvement (15 % vs. 6 %, p = 0.04). Typical clinical features of mucomorhycosis were localized pain syndrome (53 % vs. 5 %, p = 0.0001), hemoptysis (32 % vs. 6 %, p = 0.001), on lung computed tomography scan – pleural effusion (53 % vs. 7 %, p = 0.003), lesions with destruction (38 % vs. 8 %, p = 0.0001) and “a reverse halo” symptom (17 % vs. 3 %). The overall 12-week survival was significantly lower in patients with mucormycosis (49 % vs. 81 %, p = 0.0001). In both groups unfavorable prognosis factors were: ≥2 organs involvement (p = 0.0009) and concomitant bacterial or viral infection (p = 0.001 and p = 0.008 respectively). In mucormycosis patients favorable prognosis factor was remission of underlying disease (p = 0.006), in invasive aspergillosis patients – early bronchoscopy (p = 0.003), voriconazole use (p = 0.0007) and secondary antifungal prophylaxis (p = 0.0001). |
| first_indexed | 2024-04-09T20:24:58Z |
| format | Article |
| id | doaj.art-09cd631d58aa40e1a63d80041291b819 |
| institution | Directory Open Access Journal |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| last_indexed | 2024-04-09T20:24:58Z |
| publishDate | 2018-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj.art-09cd631d58aa40e1a63d80041291b8192023-03-30T20:15:12ZrusABV-pressОнкогематология1818-83462413-40232018-07-01132394710.17650/1818-8346-2018-13-2-39-47268INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTSO. V. Shadrivova0S. N. Khostelidi1Y. A. Chudinovskikh2V. S. Zabirov3Y. V. Borzova4E. A. Desyatik5A. G. Volkova6M. O. Popova7I. V. Markova8O. S. Uspenskaya9O. S. Ruzhinskaya10T. V. Shneyder11T. S. Bogomolova12S. M. Ignatyeva13L. S. Zubarovskaya14B. V. Afanasyev15N. N. Klimko16I. Mechnikov North-Western State Medical University, Ministry of Health of RussiaI. Mechnikov North-Western State Medical University, Ministry of Health of RussiaN. Petrov National Medical research Center of Oncology, Ministry of Health of RussiaI. Mechnikov North-Western State Medical University, Ministry of Health of RussiaI. Mechnikov North-Western State Medical University, Ministry of Health of RussiaI. Mechnikov North-Western State Medical University, Ministry of Health of RussiaI.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaI.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaI.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaLeningrad Regional Clinical HospitalLeningrad Regional Clinical HospitalLeningrad Regional Clinical HospitalI. Mechnikov North-Western State Medical University, Ministry of Health of RussiaI. Mechnikov North-Western State Medical University, Ministry of Health of RussiaI.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaI.P. Pavlov First Saint Petersburg State Medical University, Ministry of Health of RussiaI. Mechnikov North-Western State Medical University, Ministry of Health of RussiaIn the retrospective multicenter study during 2007–2017 we included 59 oncohematological patients with mucormycosis and 541 patients with invasive aspergillosis. Our study showed that mucomorhycosis more often developed in children and adolescents (p = 0.001), and after «graft versus host» disease development (p = 0.0001). Patients with mucormycosis were more immunosuppressed: severe neutropenia was in 88 % vs. 82 %, median duration of neutropenia ‒ 30 days vs. 14 days, p = 0.0001, lymphocytopenia – 77 % vs. 65 %, median duration of lymphocytopenia – 25 days vs. 14 days, p = 0.001. The main sites of infection were lungs, nevertheless in patients with mucormycosis it was less frequent (73 % vs. 97 %, p = 0.02), but more frequent were ≥2 organs involvement (42 % vs. 8 %, p = 0.001) and paranasal sinuses involvement (15 % vs. 6 %, p = 0.04). Typical clinical features of mucomorhycosis were localized pain syndrome (53 % vs. 5 %, p = 0.0001), hemoptysis (32 % vs. 6 %, p = 0.001), on lung computed tomography scan – pleural effusion (53 % vs. 7 %, p = 0.003), lesions with destruction (38 % vs. 8 %, p = 0.0001) and “a reverse halo” symptom (17 % vs. 3 %). The overall 12-week survival was significantly lower in patients with mucormycosis (49 % vs. 81 %, p = 0.0001). In both groups unfavorable prognosis factors were: ≥2 organs involvement (p = 0.0009) and concomitant bacterial or viral infection (p = 0.001 and p = 0.008 respectively). In mucormycosis patients favorable prognosis factor was remission of underlying disease (p = 0.006), in invasive aspergillosis patients – early bronchoscopy (p = 0.003), voriconazole use (p = 0.0007) and secondary antifungal prophylaxis (p = 0.0001).https://oncohematology.abvpress.ru/ongm/article/view/287invasive aspergillosismucormycosisacute leukemiaaspergillusrhizopusrhizomucor |
| spellingShingle | O. V. Shadrivova S. N. Khostelidi Y. A. Chudinovskikh V. S. Zabirov Y. V. Borzova E. A. Desyatik A. G. Volkova M. O. Popova I. V. Markova O. S. Uspenskaya O. S. Ruzhinskaya T. V. Shneyder T. S. Bogomolova S. M. Ignatyeva L. S. Zubarovskaya B. V. Afanasyev N. N. Klimko INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTS Онкогематология invasive aspergillosis mucormycosis acute leukemia aspergillus rhizopus rhizomucor |
| title | INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTS |
| title_full | INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTS |
| title_fullStr | INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTS |
| title_full_unstemmed | INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTS |
| title_short | INVASIVE ASPERGILLOSIS AND MUCORMYCOSIS IN ONCOHEMATOLOGICAL PATIENTS |
| title_sort | invasive aspergillosis and mucormycosis in oncohematological patients |
| topic | invasive aspergillosis mucormycosis acute leukemia aspergillus rhizopus rhizomucor |
| url | https://oncohematology.abvpress.ru/ongm/article/view/287 |
| work_keys_str_mv | AT ovshadrivova invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT snkhostelidi invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT yachudinovskikh invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT vszabirov invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT yvborzova invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT eadesyatik invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT agvolkova invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT mopopova invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT ivmarkova invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT osuspenskaya invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT osruzhinskaya invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT tvshneyder invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT tsbogomolova invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT smignatyeva invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT lszubarovskaya invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT bvafanasyev invasiveaspergillosisandmucormycosisinoncohematologicalpatients AT nnklimko invasiveaspergillosisandmucormycosisinoncohematologicalpatients |