Three-Component Reaction of 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols

Three-Component Reaction of 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols

A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very good yields. Consecutive four-component synthesi...

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Bibliographic Details
Main Authors: Nikita E. Golantsov, Hung M. Nguyen, Alexandra S. Golubenkova, Alexey V. Varlamov, Erik V. Van der Eycken, Leonid G. Voskressensky
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Chemistry
Subjects:
multicomponent reactions
isocyanides
indoleninium ions
aryl(indol-3-yl)methylium ions
imidates
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00345/full

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