Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic Patients
Recent studies have demonstrated alterations in the topological organization of structural brain networks in diabetes mellitus (DM). However, the DM-related changes in the topological properties in functional brain networks are almost unexplored so far. We therefore used fluoro-D-glucose positron em...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-05-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00235/full |
| _version_ | 1818023852458901504 |
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| author | Qiu eXiangzhe Zhang eYanjun Feng eHongbo Jiang eDonglang |
| author_facet | Qiu eXiangzhe Zhang eYanjun Feng eHongbo Jiang eDonglang |
| author_sort | Qiu eXiangzhe |
| collection | DOAJ |
| description | Recent studies have demonstrated alterations in the topological organization of structural brain networks in diabetes mellitus (DM). However, the DM-related changes in the topological properties in functional brain networks are almost unexplored so far. We therefore used fluoro-D-glucose positron emission tomography (FDG-PET) data to construct functional brain networks of 73 DM patients and 91 sex- and age-matched normal controls (NCs), followed by a graph theoretical analysis. We found that both DM patients and NCs had a small-world topology in functional brain network. In comparison to the NC group, the DM group was found to have significantly lower small-world index, lower normalized clustering coefficients and higher normalized shortest path length. Moreover, for diabetic patients, the nodal centrality was significantly reduced in the right rectus, the right cuneus, the left middle occipital gyrus, and the left postcentral gyrus, and it was significantly increased in the orbitofrontal region of the left middle frontal gyrus, the left olfactory region, and the right paracentral lobule. Our results demonstrated that the diabetic brain was associated with disrupted topological organization in the functional PET network, thus providing the functional evidence for the abnormalities of brain networks in DM. |
| first_indexed | 2024-12-10T03:50:54Z |
| format | Article |
| id | doaj.art-09cfe15dac6e4ef98ce1b7790e78b318 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-10T03:50:54Z |
| publishDate | 2016-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-09cfe15dac6e4ef98ce1b7790e78b3182022-12-22T02:03:16ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2016-05-011010.3389/fnins.2016.00235184840Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic PatientsQiu eXiangzhe0Zhang eYanjun1Feng eHongbo2Jiang eDonglang3the First Affiliated Hospital of Dalian Medical Universitythe First Affiliated Hospital of Dalian Medical Universitythe First Affiliated Hospital of Dalian Medical Universitythe First Affiliated Hospital of Dalian Medical UniversityRecent studies have demonstrated alterations in the topological organization of structural brain networks in diabetes mellitus (DM). However, the DM-related changes in the topological properties in functional brain networks are almost unexplored so far. We therefore used fluoro-D-glucose positron emission tomography (FDG-PET) data to construct functional brain networks of 73 DM patients and 91 sex- and age-matched normal controls (NCs), followed by a graph theoretical analysis. We found that both DM patients and NCs had a small-world topology in functional brain network. In comparison to the NC group, the DM group was found to have significantly lower small-world index, lower normalized clustering coefficients and higher normalized shortest path length. Moreover, for diabetic patients, the nodal centrality was significantly reduced in the right rectus, the right cuneus, the left middle occipital gyrus, and the left postcentral gyrus, and it was significantly increased in the orbitofrontal region of the left middle frontal gyrus, the left olfactory region, and the right paracentral lobule. Our results demonstrated that the diabetic brain was associated with disrupted topological organization in the functional PET network, thus providing the functional evidence for the abnormalities of brain networks in DM.http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00235/fullnetworkPETdiabetesgraph theoryFDGsmall world |
| spellingShingle | Qiu eXiangzhe Zhang eYanjun Feng eHongbo Jiang eDonglang Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic Patients Frontiers in Neuroscience network PET diabetes graph theory FDG small world |
| title | Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic Patients |
| title_full | Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic Patients |
| title_fullStr | Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic Patients |
| title_full_unstemmed | Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic Patients |
| title_short | Positron Emission Tomography Reveals Abnormal Topological Organization in Functional Brain Network in Diabetic Patients |
| title_sort | positron emission tomography reveals abnormal topological organization in functional brain network in diabetic patients |
| topic | network PET diabetes graph theory FDG small world |
| url | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00235/full |
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