Association of necrotizing enterocolitis with antimicrobial exposure in preterm infants <32 weeks gestational age:A multicenter prospective case-control study
Objective: To assess the risk of necrotizing enterocolitis (NEC) and explore the relationship between antibiotic overexposure and disease occurrence in a large prospective birth cohort.Methods: Based on a prospective birth cohort, the study collected hospitalization data of very preterm infants (VPI...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.976487/full |
| _version_ | 1798000496281124864 |
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| author | Xiaojing Pei Yujun Gao Yan Kou Yanjie Ding Dan Li Peng Lei Lili Zuo Qiongyu Liu Naiying Miao Simmy Reddy Yonghui Yu Yonghui Yu Xuemei Sun |
| author_facet | Xiaojing Pei Yujun Gao Yan Kou Yanjie Ding Dan Li Peng Lei Lili Zuo Qiongyu Liu Naiying Miao Simmy Reddy Yonghui Yu Yonghui Yu Xuemei Sun |
| author_sort | Xiaojing Pei |
| collection | DOAJ |
| description | Objective: To assess the risk of necrotizing enterocolitis (NEC) and explore the relationship between antibiotic overexposure and disease occurrence in a large prospective birth cohort.Methods: Based on a prospective birth cohort, the study collected hospitalization data of very preterm infants (VPIs) having gestational age of less than 32 weeks from January 1, 2018, to June 30, 2021 via the China Northern Neonatal Network. Infants diagnosed with NEC ≥ stage II were included in the case group, and each case was matched for GA and birth weight for the control group. Furthermore, the risk factors for NEC were determined by statistical analyses.Results: A total of 6425 VPIs were included in this study, and 167 (2.6%) of these subjects were diagnosed with NEC ≥ stage II. The study also included 984 extremely preterm infants (gestational age <28 weeks), including 50 (5.1%) infants diagnosed with NEC ≥ stage II. In the matched case-control study, subjects had a total of antibiotic days-of-therapy for 9015 days, of which broad-spectrum antibiotics (BSAs) accounted for 77%. The antibiotic spectrum index per antibiotic day in the case group was significantly higher and was an independent risk factor for the occurrence of NEC (p = 0.001, OR = 1.13).Conclusion: The cohort of VPIs was overexposed to antiboitics. Unreasonable combination of antibiotics and overexposure to BSAs may increase the risk of NEC in preterm infants. |
| first_indexed | 2024-04-11T11:21:12Z |
| format | Article |
| id | doaj.art-09d03e8bc2c64db3a62fdadc9a897da6 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T11:21:12Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-09d03e8bc2c64db3a62fdadc9a897da62022-12-22T04:27:02ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-09-011310.3389/fphar.2022.976487976487Association of necrotizing enterocolitis with antimicrobial exposure in preterm infants <32 weeks gestational age:A multicenter prospective case-control studyXiaojing Pei0Yujun Gao1Yan Kou2Yanjie Ding3Dan Li4Peng Lei5Lili Zuo6Qiongyu Liu7Naiying Miao8Simmy Reddy9Yonghui Yu10Yonghui Yu11Xuemei Sun12Department of Neonatology, Linyi People’s Hospital, Linyi, ChinaDepartment of Neonatology, Baogang Third Hospital of Hongci Group, Baotou, ChinaDepartment of Neonatology, The First Affiliated Hospital of Shandong First Medical University, Jinan, ChinaDepartment of Neonatology, Yantai Yuhuangding Hospital, Yantai, ChinaDepartment of Neonatology, Liaocheng People’s Hospital, Liaocheng, ChinaDepartment of Neonatology, Jinan Maternity and Child Care Hospital, Jinan, ChinaDepartment of Neonatology, Zibo Maternity and Child Care Hospital, Zibo, ChinaDepartment of Neonatology, Women and Children’s Healthcare Hospital of Linyi, Linyi, ChinaDepartment of Neonatology, Hebei Petro China Central Hospital, Hebei, China0Cheeloo College of Medicine, Shandong University, Jinan, China1Department of Neonatology, Shandong Provincial Hospital, Shandong University, Jinan, China2Department of Neonatology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Neonatology, Linyi People’s Hospital, Linyi, ChinaObjective: To assess the risk of necrotizing enterocolitis (NEC) and explore the relationship between antibiotic overexposure and disease occurrence in a large prospective birth cohort.Methods: Based on a prospective birth cohort, the study collected hospitalization data of very preterm infants (VPIs) having gestational age of less than 32 weeks from January 1, 2018, to June 30, 2021 via the China Northern Neonatal Network. Infants diagnosed with NEC ≥ stage II were included in the case group, and each case was matched for GA and birth weight for the control group. Furthermore, the risk factors for NEC were determined by statistical analyses.Results: A total of 6425 VPIs were included in this study, and 167 (2.6%) of these subjects were diagnosed with NEC ≥ stage II. The study also included 984 extremely preterm infants (gestational age <28 weeks), including 50 (5.1%) infants diagnosed with NEC ≥ stage II. In the matched case-control study, subjects had a total of antibiotic days-of-therapy for 9015 days, of which broad-spectrum antibiotics (BSAs) accounted for 77%. The antibiotic spectrum index per antibiotic day in the case group was significantly higher and was an independent risk factor for the occurrence of NEC (p = 0.001, OR = 1.13).Conclusion: The cohort of VPIs was overexposed to antiboitics. Unreasonable combination of antibiotics and overexposure to BSAs may increase the risk of NEC in preterm infants.https://www.frontiersin.org/articles/10.3389/fphar.2022.976487/fullnecrotizing enterocolitisvery preterm infantsmulticenterantimicrobial exposurecase-control study |
| spellingShingle | Xiaojing Pei Yujun Gao Yan Kou Yanjie Ding Dan Li Peng Lei Lili Zuo Qiongyu Liu Naiying Miao Simmy Reddy Yonghui Yu Yonghui Yu Xuemei Sun Association of necrotizing enterocolitis with antimicrobial exposure in preterm infants <32 weeks gestational age:A multicenter prospective case-control study Frontiers in Pharmacology necrotizing enterocolitis very preterm infants multicenter antimicrobial exposure case-control study |
| title | Association of necrotizing enterocolitis with antimicrobial exposure in preterm infants <32 weeks gestational age:A multicenter prospective case-control study |
| title_full | Association of necrotizing enterocolitis with antimicrobial exposure in preterm infants <32 weeks gestational age:A multicenter prospective case-control study |
| title_fullStr | Association of necrotizing enterocolitis with antimicrobial exposure in preterm infants <32 weeks gestational age:A multicenter prospective case-control study |
| title_full_unstemmed | Association of necrotizing enterocolitis with antimicrobial exposure in preterm infants <32 weeks gestational age:A multicenter prospective case-control study |
| title_short | Association of necrotizing enterocolitis with antimicrobial exposure in preterm infants <32 weeks gestational age:A multicenter prospective case-control study |
| title_sort | association of necrotizing enterocolitis with antimicrobial exposure in preterm infants 32 weeks gestational age a multicenter prospective case control study |
| topic | necrotizing enterocolitis very preterm infants multicenter antimicrobial exposure case-control study |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.976487/full |
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