The ocular benefits of estrogen replacement therapy: a population-based study in postmenopausal Korean women.
PURPOSE: To elucidate the prevalence of cataract, glaucoma, pterygia, and diabetic retinopathy among Korean postmenopausal women with or without estrogen replacement therapy (ERT). METHODS: A cross-sectional, nationally representative sample from the 4th Korea National Health and Nutrition Examinati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4161336?pdf=render |
| _version_ | 1818538740097744896 |
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| author | Kyung-Sun Na Dong Hyun Jee Kyungdo Han Yong-Gyu Park Man Soo Kim Eun Chul Kim |
| author_facet | Kyung-Sun Na Dong Hyun Jee Kyungdo Han Yong-Gyu Park Man Soo Kim Eun Chul Kim |
| author_sort | Kyung-Sun Na |
| collection | DOAJ |
| description | PURPOSE: To elucidate the prevalence of cataract, glaucoma, pterygia, and diabetic retinopathy among Korean postmenopausal women with or without estrogen replacement therapy (ERT). METHODS: A cross-sectional, nationally representative sample from the 4th Korea National Health and Nutrition Examination Survey (KNHANES IV) (2007-2009) was used. Participants were interviewed for the determination of socioeconomic and gynecologic factors. Each woman also underwent an ophthalmologic examination and provided a blood sample for risk factor assessment. RESULTS: Of 3968 postmenopausal women enrolled, 3390 had never received estrogen, and 578 were undergoing estrogen treatment. After adjusting for age, diabetes, hypertension, high cholesterol levels, and high low-density lipoprotein levels, the prevalence of anterior polar cataract, retinal nerve fiber layer (RNFL) defect, and flesh pterygium was higher in the non-ERT group (OR, 3.24; 95% CI, 1.12-9.35, OR 1.70; 95% CI, 1.04-2.78, OR 3.725; 95% CI, 1.21-11.45, respectively). Further, the prevalence of atrophic pterygium was lower in the non-ERT group compared to that in the ERT group (OR, 0.21, 95% CI, 0.07-0.63). CONCLUSIONS: These data suggest that ERT has a protective effect against the development of anterior polar cataract, flesh pterygium, and RNFL defect. |
| first_indexed | 2024-12-11T21:32:52Z |
| format | Article |
| id | doaj.art-09d0c467bbaf494b9b5d0204dba3e374 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T21:32:52Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-09d0c467bbaf494b9b5d0204dba3e3742022-12-22T00:50:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10647310.1371/journal.pone.0106473The ocular benefits of estrogen replacement therapy: a population-based study in postmenopausal Korean women.Kyung-Sun NaDong Hyun JeeKyungdo HanYong-Gyu ParkMan Soo KimEun Chul KimPURPOSE: To elucidate the prevalence of cataract, glaucoma, pterygia, and diabetic retinopathy among Korean postmenopausal women with or without estrogen replacement therapy (ERT). METHODS: A cross-sectional, nationally representative sample from the 4th Korea National Health and Nutrition Examination Survey (KNHANES IV) (2007-2009) was used. Participants were interviewed for the determination of socioeconomic and gynecologic factors. Each woman also underwent an ophthalmologic examination and provided a blood sample for risk factor assessment. RESULTS: Of 3968 postmenopausal women enrolled, 3390 had never received estrogen, and 578 were undergoing estrogen treatment. After adjusting for age, diabetes, hypertension, high cholesterol levels, and high low-density lipoprotein levels, the prevalence of anterior polar cataract, retinal nerve fiber layer (RNFL) defect, and flesh pterygium was higher in the non-ERT group (OR, 3.24; 95% CI, 1.12-9.35, OR 1.70; 95% CI, 1.04-2.78, OR 3.725; 95% CI, 1.21-11.45, respectively). Further, the prevalence of atrophic pterygium was lower in the non-ERT group compared to that in the ERT group (OR, 0.21, 95% CI, 0.07-0.63). CONCLUSIONS: These data suggest that ERT has a protective effect against the development of anterior polar cataract, flesh pterygium, and RNFL defect.http://europepmc.org/articles/PMC4161336?pdf=render |
| spellingShingle | Kyung-Sun Na Dong Hyun Jee Kyungdo Han Yong-Gyu Park Man Soo Kim Eun Chul Kim The ocular benefits of estrogen replacement therapy: a population-based study in postmenopausal Korean women. PLoS ONE |
| title | The ocular benefits of estrogen replacement therapy: a population-based study in postmenopausal Korean women. |
| title_full | The ocular benefits of estrogen replacement therapy: a population-based study in postmenopausal Korean women. |
| title_fullStr | The ocular benefits of estrogen replacement therapy: a population-based study in postmenopausal Korean women. |
| title_full_unstemmed | The ocular benefits of estrogen replacement therapy: a population-based study in postmenopausal Korean women. |
| title_short | The ocular benefits of estrogen replacement therapy: a population-based study in postmenopausal Korean women. |
| title_sort | ocular benefits of estrogen replacement therapy a population based study in postmenopausal korean women |
| url | http://europepmc.org/articles/PMC4161336?pdf=render |
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