Role of Plant-Derived Compounds in the Molecular Pathways Related to Inflammation
Inflammation is the primary response to infection and injury. Its beneficial effect is an immediate resolution of the pathophysiological event. However, sustained production of inflammatory mediators such as reactive oxygen species and cytokines may cause alterations in DNA integrity and lead to mal...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/5/4666 |
| _version_ | 1797615132723904512 |
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| author | Agata J. Olędzka Monika E. Czerwińska |
| author_facet | Agata J. Olędzka Monika E. Czerwińska |
| author_sort | Agata J. Olędzka |
| collection | DOAJ |
| description | Inflammation is the primary response to infection and injury. Its beneficial effect is an immediate resolution of the pathophysiological event. However, sustained production of inflammatory mediators such as reactive oxygen species and cytokines may cause alterations in DNA integrity and lead to malignant cell transformation and cancer. More attention has recently been paid to pyroptosis, which is an inflammatory necrosis that activates inflammasomes and the secretion of cytokines. Taking into consideration that phenolic compounds are widely available in diet and medicinal plants, their role in the prevention and support of the treatment of chronic diseases is apparent. Recently, much attention has been paid to explaining the significance of isolated compounds in the molecular pathways related to inflammation. Therefore, this review aimed to screen reports concerning the molecular mode of action assigned to phenolic compounds. The most representative compounds from the classes of flavonoids, tannins, phenolic acids, and phenolic glycosides were selected for this review. Our attention was focused mainly on nuclear factor-κB (NF-κB), nuclear factor erythroid 2-related factor 2 (Nrf2), and mitogen-activated protein kinase (MAPK) signaling pathways. Literature searching was performed using Scopus, PubMed, and Medline databases. In conclusion, based on the available literature, phenolic compounds regulate NF-κB, Nrf2, and MAPK signaling, which supports their potential role in chronic inflammatory disorders, including osteoarthritis, neurodegenerative diseases, cardiovascular, and pulmonary disorders. |
| first_indexed | 2024-03-11T07:22:10Z |
| format | Article |
| id | doaj.art-09d0c7f18d724abea3744f24a8d9203e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T07:22:10Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-09d0c7f18d724abea3744f24a8d9203e2023-11-17T07:51:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01245466610.3390/ijms24054666Role of Plant-Derived Compounds in the Molecular Pathways Related to InflammationAgata J. Olędzka0Monika E. Czerwińska1Department of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, PolandDepartment of Biochemistry and Pharmacogenomics, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Str., 02-097 Warsaw, PolandInflammation is the primary response to infection and injury. Its beneficial effect is an immediate resolution of the pathophysiological event. However, sustained production of inflammatory mediators such as reactive oxygen species and cytokines may cause alterations in DNA integrity and lead to malignant cell transformation and cancer. More attention has recently been paid to pyroptosis, which is an inflammatory necrosis that activates inflammasomes and the secretion of cytokines. Taking into consideration that phenolic compounds are widely available in diet and medicinal plants, their role in the prevention and support of the treatment of chronic diseases is apparent. Recently, much attention has been paid to explaining the significance of isolated compounds in the molecular pathways related to inflammation. Therefore, this review aimed to screen reports concerning the molecular mode of action assigned to phenolic compounds. The most representative compounds from the classes of flavonoids, tannins, phenolic acids, and phenolic glycosides were selected for this review. Our attention was focused mainly on nuclear factor-κB (NF-κB), nuclear factor erythroid 2-related factor 2 (Nrf2), and mitogen-activated protein kinase (MAPK) signaling pathways. Literature searching was performed using Scopus, PubMed, and Medline databases. In conclusion, based on the available literature, phenolic compounds regulate NF-κB, Nrf2, and MAPK signaling, which supports their potential role in chronic inflammatory disorders, including osteoarthritis, neurodegenerative diseases, cardiovascular, and pulmonary disorders.https://www.mdpi.com/1422-0067/24/5/4666MAPKNF-κBNrf-2phenolic compoundsphytotherapy |
| spellingShingle | Agata J. Olędzka Monika E. Czerwińska Role of Plant-Derived Compounds in the Molecular Pathways Related to Inflammation International Journal of Molecular Sciences MAPK NF-κB Nrf-2 phenolic compounds phytotherapy |
| title | Role of Plant-Derived Compounds in the Molecular Pathways Related to Inflammation |
| title_full | Role of Plant-Derived Compounds in the Molecular Pathways Related to Inflammation |
| title_fullStr | Role of Plant-Derived Compounds in the Molecular Pathways Related to Inflammation |
| title_full_unstemmed | Role of Plant-Derived Compounds in the Molecular Pathways Related to Inflammation |
| title_short | Role of Plant-Derived Compounds in the Molecular Pathways Related to Inflammation |
| title_sort | role of plant derived compounds in the molecular pathways related to inflammation |
| topic | MAPK NF-κB Nrf-2 phenolic compounds phytotherapy |
| url | https://www.mdpi.com/1422-0067/24/5/4666 |
| work_keys_str_mv | AT agatajoledzka roleofplantderivedcompoundsinthemolecularpathwaysrelatedtoinflammation AT monikaeczerwinska roleofplantderivedcompoundsinthemolecularpathwaysrelatedtoinflammation |