Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease

Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (α-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid–...

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Bibliographic Details
Main Authors:	Kaiying Hou, Tingting Liu, Jingwen Li, Meiyan Xian, Lin Sun, Jianshe Wei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-09-01
Series:	Frontiers in Neuroscience
Subjects:	liquid-liquid phase separation Parkinson’s disease mitophagy alpha-synuclein PINK1-Parkin
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2023.1250532/full

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