Advances in the natural α‐glucosidase inhibitors
Abstract α‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a lowering effect on postprandial blood glucose and insulin levels. Natural products are a great source for the devel...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-10-01
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| Series: | eFood |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/efd2.112 |
| _version_ | 1797659487368118272 |
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| author | Didem Şöhretoğlu Gülin Renda Randolph Arroo Jianbo Xiao Suat Sari |
| author_facet | Didem Şöhretoğlu Gülin Renda Randolph Arroo Jianbo Xiao Suat Sari |
| author_sort | Didem Şöhretoğlu |
| collection | DOAJ |
| description | Abstract α‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a lowering effect on postprandial blood glucose and insulin levels. Natural products are a great source for the development of new AG inhibitory drug candidates. We aim to summarize advances in natural AG inhibitors according to their secondary metabolite groups in the last decade. Their mechanisms of action and structure–activity relationships will especially be discussed. |
| first_indexed | 2024-03-11T18:15:47Z |
| format | Article |
| id | doaj.art-09d1faea199f43b2add03955f98e1235 |
| institution | Directory Open Access Journal |
| issn | 2666-3066 |
| language | English |
| last_indexed | 2024-03-11T18:15:47Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | eFood |
| spelling | doaj.art-09d1faea199f43b2add03955f98e12352023-10-16T07:06:48ZengWileyeFood2666-30662023-10-0145n/an/a10.1002/efd2.112Advances in the natural α‐glucosidase inhibitorsDidem Şöhretoğlu0Gülin Renda1Randolph Arroo2Jianbo Xiao3Suat Sari4Department of Pharmacognosy, Faculty of Pharmacy Hacettepe University Ankara TurkeyDepartment of Pharmacognosy Karadeniz Technical University Trabzon TurkeyLeicester School of Pharmacy De Montfort University Leicester UKDepartment of Analytical Chemistry and Food Science, Faculty of Food Science and Technology University of Vigo Vigo SpainDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy Hacettepe University Ankara TurkeyAbstract α‐Glucosidase (AG) inhibitors, one of the classes of oral antidiabetics used to treat type 2 diabetes mellitus, delay digestion and absorption of glucose, which in turn, has a lowering effect on postprandial blood glucose and insulin levels. Natural products are a great source for the development of new AG inhibitory drug candidates. We aim to summarize advances in natural AG inhibitors according to their secondary metabolite groups in the last decade. Their mechanisms of action and structure–activity relationships will especially be discussed.https://doi.org/10.1002/efd2.112α‐glucosidasediabetesflavonoidpolyphenoltanninterpene |
| spellingShingle | Didem Şöhretoğlu Gülin Renda Randolph Arroo Jianbo Xiao Suat Sari Advances in the natural α‐glucosidase inhibitors eFood α‐glucosidase diabetes flavonoid polyphenol tannin terpene |
| title | Advances in the natural α‐glucosidase inhibitors |
| title_full | Advances in the natural α‐glucosidase inhibitors |
| title_fullStr | Advances in the natural α‐glucosidase inhibitors |
| title_full_unstemmed | Advances in the natural α‐glucosidase inhibitors |
| title_short | Advances in the natural α‐glucosidase inhibitors |
| title_sort | advances in the natural α glucosidase inhibitors |
| topic | α‐glucosidase diabetes flavonoid polyphenol tannin terpene |
| url | https://doi.org/10.1002/efd2.112 |
| work_keys_str_mv | AT didemsohretoglu advancesinthenaturalaglucosidaseinhibitors AT gulinrenda advancesinthenaturalaglucosidaseinhibitors AT randolpharroo advancesinthenaturalaglucosidaseinhibitors AT jianboxiao advancesinthenaturalaglucosidaseinhibitors AT suatsari advancesinthenaturalaglucosidaseinhibitors |