Whole Animal Feeding FLat (WAFFL): a complete and comprehensive validation of a novel, high-throughput fly experimentation system
AbstractNon-mammalian model organisms have been essential for our understanding of the mechanisms that control development, disease, and physiology, but they are underutilized in pharmacological and toxicological phenotypic screening assays due to their low throughput in comparison w...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Oxford University Press
2023-01-01
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| Series: | G3: Genes, Genomes, Genetics |
| Online Access: | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkad012 |
| _version_ | 1797788916829388800 |
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| author | Maria D L A Jaime Ghadi H Salem Daniel J Martinez Sean Karott Alejandra Flores Cameron D Palmer Sharvani Mahadevaraju Jonathan Krynitsky Marcial Garmendia-Cedillos Sarah Anderson Susan Harbison Thomas J Pohida William B Ludington Brian Oliver |
| author_facet | Maria D L A Jaime Ghadi H Salem Daniel J Martinez Sean Karott Alejandra Flores Cameron D Palmer Sharvani Mahadevaraju Jonathan Krynitsky Marcial Garmendia-Cedillos Sarah Anderson Susan Harbison Thomas J Pohida William B Ludington Brian Oliver |
| author_sort | Maria D L A Jaime |
| collection | DOAJ |
| description |
AbstractNon-mammalian model organisms have been essential for our understanding of the mechanisms that control development, disease, and physiology, but they are underutilized in pharmacological and toxicological phenotypic screening assays due to their low throughput in comparison with cell-based screens. To increase the utility of using Drosophila melanogaster |
| first_indexed | 2024-03-13T01:42:20Z |
| format | Article |
| id | doaj.art-09d3ccb0043d4e1191fa6104f91410a9 |
| institution | Directory Open Access Journal |
| issn | 2160-1836 |
| language | English |
| last_indexed | 2024-03-13T01:42:20Z |
| publishDate | 2023-01-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | G3: Genes, Genomes, Genetics |
| spelling | doaj.art-09d3ccb0043d4e1191fa6104f91410a92023-07-03T11:11:28ZengOxford University PressG3: Genes, Genomes, Genetics2160-18362023-01-0113310.1093/g3journal/jkad012Whole Animal Feeding FLat (WAFFL): a complete and comprehensive validation of a novel, high-throughput fly experimentation systemMaria D L A Jaime0Ghadi H Salem1Daniel J Martinez2Sean Karott3Alejandra Flores4Cameron D Palmer5Sharvani Mahadevaraju6Jonathan Krynitsky7Marcial Garmendia-Cedillos8Sarah Anderson9Susan Harbison10https://orcid.org/0000-0001-7233-0947Thomas J Pohida11William B Ludington12https://orcid.org/0000-0001-9637-4493Brian Oliver13https://orcid.org/0000-0002-3455-4891Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21218, USAInstrument Development and Engineering Application Solutions, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 12 South Dr, Bethesda, MD 20892, USADepartment of Embryology, Carnegie Institution of Washington, Baltimore, MD 21218, USALaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20814, USALaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20814, USALaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20814, USALaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20814, USAInstrument Development and Engineering Application Solutions, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 12 South Dr, Bethesda, MD 20892, USAInstrument Development and Engineering Application Solutions, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 12 South Dr, Bethesda, MD 20892, USAInstrument Development and Engineering Application Solutions, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 12 South Dr, Bethesda, MD 20892, USALaboratory of Systems Genetics, National Heart Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20814, USAInstrument Development and Engineering Application Solutions, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 12 South Dr, Bethesda, MD 20892, USADepartment of Embryology, Carnegie Institution of Washington, Baltimore, MD 21218, USALaboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 50 South Drive, Bethesda, MD 20814, USA AbstractNon-mammalian model organisms have been essential for our understanding of the mechanisms that control development, disease, and physiology, but they are underutilized in pharmacological and toxicological phenotypic screening assays due to their low throughput in comparison with cell-based screens. To increase the utility of using Drosophila melanogasterhttps://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkad012 |
| spellingShingle | Maria D L A Jaime Ghadi H Salem Daniel J Martinez Sean Karott Alejandra Flores Cameron D Palmer Sharvani Mahadevaraju Jonathan Krynitsky Marcial Garmendia-Cedillos Sarah Anderson Susan Harbison Thomas J Pohida William B Ludington Brian Oliver Whole Animal Feeding FLat (WAFFL): a complete and comprehensive validation of a novel, high-throughput fly experimentation system G3: Genes, Genomes, Genetics |
| title | Whole Animal Feeding FLat (WAFFL): a complete and comprehensive validation of a novel, high-throughput fly experimentation system |
| title_full | Whole Animal Feeding FLat (WAFFL): a complete and comprehensive validation of a novel, high-throughput fly experimentation system |
| title_fullStr | Whole Animal Feeding FLat (WAFFL): a complete and comprehensive validation of a novel, high-throughput fly experimentation system |
| title_full_unstemmed | Whole Animal Feeding FLat (WAFFL): a complete and comprehensive validation of a novel, high-throughput fly experimentation system |
| title_short | Whole Animal Feeding FLat (WAFFL): a complete and comprehensive validation of a novel, high-throughput fly experimentation system |
| title_sort | whole animal feeding flat waffl a complete and comprehensive validation of a novel high throughput fly experimentation system |
| url | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkad012 |
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