Small-Molecule-Induced Activation of Cellular Respiration Inhibits Biofilm Formation and Triggers Metabolic Remodeling in Staphylococcus aureus

Small-Molecule-Induced Activation of Cellular Respiration Inhibits Biofilm Formation and Triggers Metabolic Remodeling in Staphylococcus aureus

ABSTRACT Staphylococcus aureus, a major pathogen of community-acquired and nosocomial-associated infections, forms biofilms consisting of extracellular matrix-embedded cell aggregates. S. aureus biofilm formation on implanted medical devices can cause local and systemic infections due to the dispers...

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Bibliographic Details
Main Authors: Ken-ichi Okuda, Satomi Yamada-Ueno, Yutaka Yoshii, Tetsuo Nagano, Takayoshi Okabe, Hirotatsu Kojima, Yoshimitsu Mizunoe, Yuki Kinjo
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
biofilms
Staphylococcus aureus
high-throughput screening
cellular respiration
aminoglycoside
Online Access:https://journals.asm.org/doi/10.1128/mbio.00845-22

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