Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids

Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids

Three-dimensional (3D) cell spheroid models combined with mass spectrometry imaging (MSI) enables innovative investigation of in vivo-like biological processes under different physiological and pathological conditions. Herein, airflow-assisted desorption electrospray ionization-MSI (AFADESI-MSI) was...

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Bibliographic Details
Main Authors: Limei Li, Qingce Zang, Xinzhu Li, Ying Zhu, Shanjing Wen, Jiuming He, Ruiping Zhang, Zeper Abliz
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Mass spectrometry imaging
HepG2 spheroids
Hepatotoxicity
Drug metabolism
Amiodarone
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177923000679

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