Mouse embryonic stem cells can differentiate via multiple paths to the same state

Mouse embryonic stem cells can differentiate via multiple paths to the same state

In embryonic development, cells differentiate through stereotypical sequences of intermediate states to generate particular mature fates. By contrast, driving differentiation by ectopically expressing terminal transcription factors (direct programming) can generate similar fates by alternative route...

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Bibliographic Details
Main Authors: James Alexander Briggs, Victor C Li, Seungkyu Lee, Clifford J Woolf, Allon Klein, Marc W Kirschner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
stem cell differentiation
direct programming
single cell RNA-seq
motor neuron
differentiation trajectory
embryonic development
Online Access:https://elifesciences.org/articles/26945

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