SARS-CoV-2-Associated ssRNAs Activate Human Neutrophils in a TLR8-Dependent Fashion

SARS-CoV-2-Associated ssRNAs Activate Human Neutrophils in a TLR8-Dependent Fashion

COVID-19 disease is characterized by a dysregulation of the innate arm of the immune system. However, the mechanisms whereby innate immune cells, including neutrophils, become activated in patients are not completely understood. Recently, we showed that GU-rich RNA sequences from the SARS-CoV-2 geno...

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Bibliographic Details
Main Authors: Elisa Gardiman, Francisco Bianchetto-Aguilera, Sara Gasperini, Laura Tiberio, Matteo Scandola, Virginia Lotti, Davide Gibellini, Valentina Salvi, Daniela Bosisio, Marco A. Cassatella, Nicola Tamassia
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
neutrophils
TLR8
SARS-CoV-2
ssRNA
RNA-seq
neutrophil extracellular trap
Online Access:https://www.mdpi.com/2073-4409/11/23/3785

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