The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes
The autoimmune disease, Type 1 Diabetes Mellitus (T1DM), results in the destruction of pancreatic β-cells, and the International Diabetes Federation reports that its incidence is increasing worldwide. T1DM is a complex disease due to the interaction between genetic and environmental factors. Certain...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2020.612115/full |
| _version_ | 1818603237045960704 |
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| author | Amira Kohil Maha Al-Asmakh Maha Al-Asmakh Maha Al-Asmakh Mashael Al-Shafai Mashael Al-Shafai Annalisa Terranegra |
| author_facet | Amira Kohil Maha Al-Asmakh Maha Al-Asmakh Maha Al-Asmakh Mashael Al-Shafai Mashael Al-Shafai Annalisa Terranegra |
| author_sort | Amira Kohil |
| collection | DOAJ |
| description | The autoimmune disease, Type 1 Diabetes Mellitus (T1DM), results in the destruction of pancreatic β-cells, and the International Diabetes Federation reports that its incidence is increasing worldwide. T1DM is a complex disease due to the interaction between genetic and environmental factors. Certain dietary patterns and nutrients are known to cause epigenetic modifications in physiological conditions and diseases. However, the interplay between diet and epigenetics is not yet well-understood in the context of T1DM. Several studies have described epigenetic mechanisms involved in the autoimmune reactions that destroy the β-cells, but few explored diet components as potential triggers for epigenetic modifications. Clarifying the link between diet and epigenome can provide new insights into the pathogenesis of T1DM, potentially leading to new diagnostic and therapeutic approaches. In this mini review, we shed light on the influence of the diet-epigenome axis on the pathophysiology of T1DM. |
| first_indexed | 2024-12-16T13:19:58Z |
| format | Article |
| id | doaj.art-09d95441fa8b4c5292fa23e30a7c754a |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-16T13:19:58Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-09d95441fa8b4c5292fa23e30a7c754a2022-12-21T22:30:22ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-01-01710.3389/fnut.2020.612115612115The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 DiabetesAmira Kohil0Maha Al-Asmakh1Maha Al-Asmakh2Maha Al-Asmakh3Mashael Al-Shafai4Mashael Al-Shafai5Annalisa Terranegra6Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, QatarDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, QatarBiomedical Research Center, Qatar University, Doha, QatarBiomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, QatarDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, QatarBiomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, QatarResearch Branch, Sidra Medicine, Doha, QatarThe autoimmune disease, Type 1 Diabetes Mellitus (T1DM), results in the destruction of pancreatic β-cells, and the International Diabetes Federation reports that its incidence is increasing worldwide. T1DM is a complex disease due to the interaction between genetic and environmental factors. Certain dietary patterns and nutrients are known to cause epigenetic modifications in physiological conditions and diseases. However, the interplay between diet and epigenetics is not yet well-understood in the context of T1DM. Several studies have described epigenetic mechanisms involved in the autoimmune reactions that destroy the β-cells, but few explored diet components as potential triggers for epigenetic modifications. Clarifying the link between diet and epigenome can provide new insights into the pathogenesis of T1DM, potentially leading to new diagnostic and therapeutic approaches. In this mini review, we shed light on the influence of the diet-epigenome axis on the pathophysiology of T1DM.https://www.frontiersin.org/articles/10.3389/fnut.2020.612115/fulltype 1 diabetesdietepigeneticshistone modificationsDNA methylationmicro-RNA |
| spellingShingle | Amira Kohil Maha Al-Asmakh Maha Al-Asmakh Maha Al-Asmakh Mashael Al-Shafai Mashael Al-Shafai Annalisa Terranegra The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes Frontiers in Nutrition type 1 diabetes diet epigenetics histone modifications DNA methylation micro-RNA |
| title | The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes |
| title_full | The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes |
| title_fullStr | The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes |
| title_full_unstemmed | The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes |
| title_short | The Interplay Between Diet and the Epigenome in the Pathogenesis of Type-1 Diabetes |
| title_sort | interplay between diet and the epigenome in the pathogenesis of type 1 diabetes |
| topic | type 1 diabetes diet epigenetics histone modifications DNA methylation micro-RNA |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2020.612115/full |
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