Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An 123I-FP-CIT SPECT study
Purpose: To study the influence of concomitant Alzheimer's disease (AD) pathology in dementia with Lewy bodies (DLB) on dopamine transporter (DAT) and serotonin transporter (SERT) availability, using 123I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (123I-FP-CIT) single photon...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
|
| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158219304097 |
| _version_ | 1818040515391651840 |
|---|---|
| author | J.J. van der Zande M. Joling I.G. Happach C. Vriend Ph. Scheltens J. Booij A.W. Lemstra |
| author_facet | J.J. van der Zande M. Joling I.G. Happach C. Vriend Ph. Scheltens J. Booij A.W. Lemstra |
| author_sort | J.J. van der Zande |
| collection | DOAJ |
| description | Purpose: To study the influence of concomitant Alzheimer's disease (AD) pathology in dementia with Lewy bodies (DLB) on dopamine transporter (DAT) and serotonin transporter (SERT) availability, using 123I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (123I-FP-CIT) single photon emission computed tomography (SPECT). Methods: Based on their cerebrospinal fluid biomarker profile, fifty-two patients with probable DLB were divided in a group with (DLB/AD+, N = 15) and without concomitant AD-pathology (DLB/AD-, N = 37). We conducted atrophy-corrected region of interest (ROI) analyses comparing binding ratios (BRs) in the DAT-rich striatal and SERT-rich extrastriatal brain areas (amygdala, hippocampus, thalamus, midbrain and pons). Results: DLB/AD+ patients had significantly lower 123I-FP-CIT BRs in the left amygdala, and a trend was seen in the right hippocampus. Groups did not differ significantly in striatal 123I-FP-CIT BRs, neuropsychiatric or motor symptoms. Motor symptoms correlated negatively with striatal DAT BRs. Conclusions: DLB/AD+ patients may have lower SERT binding in limbic brain regions than DLB/AD- patients, possibly indicating faster neurodegeneration in mixed pathology. Keywords: Dementia with Lewy bodies, Alzheime’s disease, Dopamine transporter, Serotonin transporter, 123I-FP-CIT SPECT |
| first_indexed | 2024-12-10T08:15:45Z |
| format | Article |
| id | doaj.art-09d9aa1ea898495d9b2045a7632659bb |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-10T08:15:45Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-09d9aa1ea898495d9b2045a7632659bb2022-12-22T01:56:28ZengElsevierNeuroImage: Clinical2213-15822020-01-0125Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An 123I-FP-CIT SPECT studyJ.J. van der Zande0M. Joling1I.G. Happach2C. Vriend3Ph. Scheltens4J. Booij5A.W. Lemstra6Amsterdam UMC, Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, the Netherlands; Corresponding author. Alzheimer Center Amsterdam, Amsterdam UMC de Boelelaan 1118 1081 HZ Amsterdam, the NetherlandsAmsterdam UMC, Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, the NetherlandsAmsterdam UMC, Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, the NetherlandsAmsterdam UMC, Vrije Universiteit Amsterdam, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, the NetherlandsAmsterdam UMC, Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, the NetherlandsAmsterdam UMC, Academic Medical Center, Department of Radiology and Nuclear Medicine, Amsterdam, the NetherlandsAmsterdam UMC, Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit, Amsterdam, the NetherlandsPurpose: To study the influence of concomitant Alzheimer's disease (AD) pathology in dementia with Lewy bodies (DLB) on dopamine transporter (DAT) and serotonin transporter (SERT) availability, using 123I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl) nortropane (123I-FP-CIT) single photon emission computed tomography (SPECT). Methods: Based on their cerebrospinal fluid biomarker profile, fifty-two patients with probable DLB were divided in a group with (DLB/AD+, N = 15) and without concomitant AD-pathology (DLB/AD-, N = 37). We conducted atrophy-corrected region of interest (ROI) analyses comparing binding ratios (BRs) in the DAT-rich striatal and SERT-rich extrastriatal brain areas (amygdala, hippocampus, thalamus, midbrain and pons). Results: DLB/AD+ patients had significantly lower 123I-FP-CIT BRs in the left amygdala, and a trend was seen in the right hippocampus. Groups did not differ significantly in striatal 123I-FP-CIT BRs, neuropsychiatric or motor symptoms. Motor symptoms correlated negatively with striatal DAT BRs. Conclusions: DLB/AD+ patients may have lower SERT binding in limbic brain regions than DLB/AD- patients, possibly indicating faster neurodegeneration in mixed pathology. Keywords: Dementia with Lewy bodies, Alzheime’s disease, Dopamine transporter, Serotonin transporter, 123I-FP-CIT SPECThttp://www.sciencedirect.com/science/article/pii/S2213158219304097 |
| spellingShingle | J.J. van der Zande M. Joling I.G. Happach C. Vriend Ph. Scheltens J. Booij A.W. Lemstra Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An 123I-FP-CIT SPECT study NeuroImage: Clinical |
| title | Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An 123I-FP-CIT SPECT study |
| title_full | Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An 123I-FP-CIT SPECT study |
| title_fullStr | Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An 123I-FP-CIT SPECT study |
| title_full_unstemmed | Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An 123I-FP-CIT SPECT study |
| title_short | Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An 123I-FP-CIT SPECT study |
| title_sort | serotonergic deficits in dementia with lewy bodies with concomitant alzheimer s disease pathology an 123i fp cit spect study |
| url | http://www.sciencedirect.com/science/article/pii/S2213158219304097 |
| work_keys_str_mv | AT jjvanderzande serotonergicdeficitsindementiawithlewybodieswithconcomitantalzheimersdiseasepathologyan123ifpcitspectstudy AT mjoling serotonergicdeficitsindementiawithlewybodieswithconcomitantalzheimersdiseasepathologyan123ifpcitspectstudy AT ighappach serotonergicdeficitsindementiawithlewybodieswithconcomitantalzheimersdiseasepathologyan123ifpcitspectstudy AT cvriend serotonergicdeficitsindementiawithlewybodieswithconcomitantalzheimersdiseasepathologyan123ifpcitspectstudy AT phscheltens serotonergicdeficitsindementiawithlewybodieswithconcomitantalzheimersdiseasepathologyan123ifpcitspectstudy AT jbooij serotonergicdeficitsindementiawithlewybodieswithconcomitantalzheimersdiseasepathologyan123ifpcitspectstudy AT awlemstra serotonergicdeficitsindementiawithlewybodieswithconcomitantalzheimersdiseasepathologyan123ifpcitspectstudy |