ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair
Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I editing.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25790-2 |
| _version_ | 1828972285732585472 |
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| author | Sonia Jimeno Rosario Prados-Carvajal María Jesús Fernández-Ávila Sonia Silva Domenico Alessandro Silvestris Martín Endara-Coll Guillermo Rodríguez-Real Judit Domingo-Prim Fernando Mejías-Navarro Amador Romero-Franco Silvia Jimeno-González Sonia Barroso Valeriana Cesarini Andrés Aguilera Angela Gallo Neus Visa Pablo Huertas |
| author_facet | Sonia Jimeno Rosario Prados-Carvajal María Jesús Fernández-Ávila Sonia Silva Domenico Alessandro Silvestris Martín Endara-Coll Guillermo Rodríguez-Real Judit Domingo-Prim Fernando Mejías-Navarro Amador Romero-Franco Silvia Jimeno-González Sonia Barroso Valeriana Cesarini Andrés Aguilera Angela Gallo Neus Visa Pablo Huertas |
| author_sort | Sonia Jimeno |
| collection | DOAJ |
| description | Different roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I editing. |
| first_indexed | 2024-12-14T13:24:56Z |
| format | Article |
| id | doaj.art-09d9d77f3a254b6e952ffa2219df630e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:24:56Z |
| publishDate | 2021-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-09d9d77f3a254b6e952ffa2219df630e2022-12-21T22:59:51ZengNature PortfolioNature Communications2041-17232021-09-0112111510.1038/s41467-021-25790-2ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repairSonia Jimeno0Rosario Prados-Carvajal1María Jesús Fernández-Ávila2Sonia Silva3Domenico Alessandro Silvestris4Martín Endara-Coll5Guillermo Rodríguez-Real6Judit Domingo-Prim7Fernando Mejías-Navarro8Amador Romero-Franco9Silvia Jimeno-González10Sonia Barroso11Valeriana Cesarini12Andrés Aguilera13Angela Gallo14Neus Visa15Pablo Huertas16Departamento de Genética, Universidad de SevillaDepartamento de Genética, Universidad de SevillaCentro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de OlavideDepartamento de Genética, Universidad de SevillaRNA Editing Lab, Oncohaematology Department, IRCCS Ospedale Pediatrico “Bambino Gesù”Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartamento de Genética, Universidad de SevillaDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartamento de Genética, Universidad de SevillaDepartamento de Genética, Universidad de SevillaDepartamento de Genética, Universidad de SevillaDepartamento de Genética, Universidad de SevillaRNA Editing Lab, Oncohaematology Department, IRCCS Ospedale Pediatrico “Bambino Gesù”Departamento de Genética, Universidad de SevillaRNA Editing Lab, Oncohaematology Department, IRCCS Ospedale Pediatrico “Bambino Gesù”Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm UniversityDepartamento de Genética, Universidad de SevillaDifferent roles of specific RNA-related factors in DNA repair have now been reported. Here the authors reveal a role for RNA-editing by ADAR in DNA end resection following double strand break formation and a change in pattern of ADAR2-mediated A-to-I editing.https://doi.org/10.1038/s41467-021-25790-2 |
| spellingShingle | Sonia Jimeno Rosario Prados-Carvajal María Jesús Fernández-Ávila Sonia Silva Domenico Alessandro Silvestris Martín Endara-Coll Guillermo Rodríguez-Real Judit Domingo-Prim Fernando Mejías-Navarro Amador Romero-Franco Silvia Jimeno-González Sonia Barroso Valeriana Cesarini Andrés Aguilera Angela Gallo Neus Visa Pablo Huertas ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair Nature Communications |
| title | ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair |
| title_full | ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair |
| title_fullStr | ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair |
| title_full_unstemmed | ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair |
| title_short | ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair |
| title_sort | adar mediated rna editing of dna rna hybrids is required for dna double strand break repair |
| url | https://doi.org/10.1038/s41467-021-25790-2 |
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