Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms.

Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms.

People with HIV (PWH) are at increased risk for atherosclerotic cardiovascular disease (ASCVD). Proportions of vascular homing monocytes are enriched in PWH; however, little is known regarding monocyte-derived macrophages (MDMs) that may drive atherosclerosis in this population. We isolated PBMCs fr...

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Bibliographic Details
Main Authors: Emily R Bowman, Cheryl M Cameron, Brian Richardson, Manjusha Kulkarni, Janelle Gabriel, Morgan J Cichon, Kenneth M Riedl, Yousef Mustafa, Michael Cartwright, Brandon Snyder, Subha V Raman, David A Zidar, Susan L Koletar, Martin P Playford, Nehal N Mehta, Scott F Sieg, Michael L Freeman, Michael M Lederman, Mark J Cameron, Nicholas T Funderburg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008869

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