Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance
Abstract The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Journal of Inflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12950-023-00333-2 |
| _version_ | 1797865581127401472 |
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| author | Gaetano Scaramuzzo Francesco Nucera Alessio Asmundo Roberto Messina Matilde Mari Federica Montanaro Matt D. Johansen Francesco Monaco Guido Fadda Giovanni Tuccari Nicole G. Hansbro Philip M. Hansbro Trevor T. Hansel Ian M. Adcock Antonio David Paul Kirkham Gaetano Caramori Carlo Alberto Volta Savino Spadaro |
| author_facet | Gaetano Scaramuzzo Francesco Nucera Alessio Asmundo Roberto Messina Matilde Mari Federica Montanaro Matt D. Johansen Francesco Monaco Guido Fadda Giovanni Tuccari Nicole G. Hansbro Philip M. Hansbro Trevor T. Hansel Ian M. Adcock Antonio David Paul Kirkham Gaetano Caramori Carlo Alberto Volta Savino Spadaro |
| author_sort | Gaetano Scaramuzzo |
| collection | DOAJ |
| description | Abstract The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support. The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS. |
| first_indexed | 2024-04-09T23:10:25Z |
| format | Article |
| id | doaj.art-09db15bec1ab49ba975346d548e55894 |
| institution | Directory Open Access Journal |
| issn | 1476-9255 |
| language | English |
| last_indexed | 2024-04-09T23:10:25Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj.art-09db15bec1ab49ba975346d548e558942023-03-22T10:25:05ZengBMCJournal of Inflammation1476-92552023-03-0120112410.1186/s12950-023-00333-2Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevanceGaetano Scaramuzzo0Francesco Nucera1Alessio Asmundo2Roberto Messina3Matilde Mari4Federica Montanaro5Matt D. Johansen6Francesco Monaco7Guido Fadda8Giovanni Tuccari9Nicole G. Hansbro10Philip M. Hansbro11Trevor T. Hansel12Ian M. Adcock13Antonio David14Paul Kirkham15Gaetano Caramori16Carlo Alberto Volta17Savino Spadaro18Department of Translational Medicine, University of FerraraPneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di MessinaMedicina Legale, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di MessinaIntensive Care Unit, Dipartimento di Patologia Umana e dell’Età Evolutiva Gaetano Barresi, Università di MessinaDepartment of Translational Medicine, University of FerraraDepartment of Translational Medicine, University of FerraraCentre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology SydneyChirurgia Toracica, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di MessinaSection of Pathological Anatomy, Department of Human Pathology of Adult and Developmental Age “Gaetano Barresi”, University of MessinaSection of Pathological Anatomy, Department of Human Pathology of Adult and Developmental Age “Gaetano Barresi”, University of MessinaCentre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology SydneyCentre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology SydneyMedical Research Council and Asthma, UK Centre in Allergic Mechanisms of AsthmaAirway Disease Section, National Heart and Lung Institute, Imperial College LondonIntensive Care Unit, Dipartimento di Patologia Umana e dell’Età Evolutiva Gaetano Barresi, Università di MessinaDepartment of Biomedical Sciences, Faculty of Sciences and Engineering, University of WolverhamptonPneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di MessinaDepartment of Translational Medicine, University of FerraraDepartment of Translational Medicine, University of FerraraAbstract The severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection can be asymptomatic or cause a disease (COVID-19) characterized by different levels of severity. The main cause of severe COVID-19 and death is represented by acute (or acute on chronic) respiratory failure and acute respiratory distress syndrome (ARDS), often requiring hospital admission and ventilator support. The molecular pathogenesis of COVID-19-related ARDS (by now termed c-ARDS) is still poorly understood. In this review we will discuss the genetic susceptibility to COVID-19, the pathogenesis and the local and systemic biomarkers correlated with c-ARDS and the therapeutic options that target the cell signalling pathways of c-ARDS.https://doi.org/10.1186/s12950-023-00333-2COVID-19SARS-CoV-2ARDSBiomarkersCytokinesChemokines |
| spellingShingle | Gaetano Scaramuzzo Francesco Nucera Alessio Asmundo Roberto Messina Matilde Mari Federica Montanaro Matt D. Johansen Francesco Monaco Guido Fadda Giovanni Tuccari Nicole G. Hansbro Philip M. Hansbro Trevor T. Hansel Ian M. Adcock Antonio David Paul Kirkham Gaetano Caramori Carlo Alberto Volta Savino Spadaro Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance Journal of Inflammation COVID-19 SARS-CoV-2 ARDS Biomarkers Cytokines Chemokines |
| title | Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance |
| title_full | Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance |
| title_fullStr | Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance |
| title_full_unstemmed | Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance |
| title_short | Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance |
| title_sort | cellular and molecular features of covid 19 associated ards therapeutic relevance |
| topic | COVID-19 SARS-CoV-2 ARDS Biomarkers Cytokines Chemokines |
| url | https://doi.org/10.1186/s12950-023-00333-2 |
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