In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin
The transdermal drug-in-adhesive (DIA) patch of simvastatin (SM) was developed using acrylic adhesives such as DURO-TAK® 87-9301, DURO-TAK® 87-4287, DURO-TAK® 87-235A. The patches were evaluated for in vitro drug permeation across the pork ear skin using diffusion cell and stability studies. Among t...
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| Format: | Article |
| Language: | English |
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Faculty of Pharmacy, Cairo University
2018-06-01
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| Series: | Bulletin of Faculty of Pharmacy Cairo University |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110093118300097 |
| _version_ | 1797967486714380288 |
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| author | Rabinarayan Parhi Suresh Padilam |
| author_facet | Rabinarayan Parhi Suresh Padilam |
| author_sort | Rabinarayan Parhi |
| collection | DOAJ |
| description | The transdermal drug-in-adhesive (DIA) patch of simvastatin (SM) was developed using acrylic adhesives such as DURO-TAK® 87-9301, DURO-TAK® 87-4287, DURO-TAK® 87-235A. The patches were evaluated for in vitro drug permeation across the pork ear skin using diffusion cell and stability studies. Among the three acrylic adhesives used, DURO-TAK® 87-9301 exhibited maximum flux (5.18 ± 0.23 µg/cm2/h). To further enhance the drug permeation, isopropyl myristate (IPM), d-limonene and 1,8-cineol as penetration enhancers (PEs) were incorporated into the DIA patch prepared from DURO-TAK® 87-9301. Out of those, IPM containing patch exhibited a flux of 16.45 ± 1.67 µg/cm2/h revealing that IPM is the best PE. The stability study was carried out on optimized fresh (SA4) and 6 months old patches stored at room and at accelerated condition (40 ± 2 °C/75 ± 5%RH) using FTIR, DSC and SEM techniques. Significant shift of peaks were not observed in FTIR spectra and DSC thermograms of the patches after the stability period. SEM micrographs of patches did not show any evidence of recrystallization indicating the presence of drug in the molecular form throughout the adhesive matrix. The investigation reveals that the DIA patch studied as above is stable and may serve as a potential drug delivery system for simvastatin. |
| first_indexed | 2024-04-11T02:31:58Z |
| format | Article |
| id | doaj.art-09db510ab9c648129333bef96fb674bb |
| institution | Directory Open Access Journal |
| issn | 1110-0931 |
| language | English |
| last_indexed | 2024-04-11T02:31:58Z |
| publishDate | 2018-06-01 |
| publisher | Faculty of Pharmacy, Cairo University |
| record_format | Article |
| series | Bulletin of Faculty of Pharmacy Cairo University |
| spelling | doaj.art-09db510ab9c648129333bef96fb674bb2023-01-02T21:10:10ZengFaculty of Pharmacy, Cairo UniversityBulletin of Faculty of Pharmacy Cairo University1110-09312018-06-01561263310.1016/j.bfopcu.2018.04.001In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatinRabinarayan Parhi0Suresh Padilam1GITAM Institute of Pharmacy, GITAM (Deemed to be University), Gandhi Nagar Campus, Rushikonda, Visakhapatnam 530045, Andhra Pradesh, IndiaSchool of Pharmacy, Guru Nanak Institutions Technical Campus (Autonomous), Hyderabad 501506, Telengana, IndiaThe transdermal drug-in-adhesive (DIA) patch of simvastatin (SM) was developed using acrylic adhesives such as DURO-TAK® 87-9301, DURO-TAK® 87-4287, DURO-TAK® 87-235A. The patches were evaluated for in vitro drug permeation across the pork ear skin using diffusion cell and stability studies. Among the three acrylic adhesives used, DURO-TAK® 87-9301 exhibited maximum flux (5.18 ± 0.23 µg/cm2/h). To further enhance the drug permeation, isopropyl myristate (IPM), d-limonene and 1,8-cineol as penetration enhancers (PEs) were incorporated into the DIA patch prepared from DURO-TAK® 87-9301. Out of those, IPM containing patch exhibited a flux of 16.45 ± 1.67 µg/cm2/h revealing that IPM is the best PE. The stability study was carried out on optimized fresh (SA4) and 6 months old patches stored at room and at accelerated condition (40 ± 2 °C/75 ± 5%RH) using FTIR, DSC and SEM techniques. Significant shift of peaks were not observed in FTIR spectra and DSC thermograms of the patches after the stability period. SEM micrographs of patches did not show any evidence of recrystallization indicating the presence of drug in the molecular form throughout the adhesive matrix. The investigation reveals that the DIA patch studied as above is stable and may serve as a potential drug delivery system for simvastatin.http://www.sciencedirect.com/science/article/pii/S1110093118300097SimvastatinDrug-in-adhesive patchAcrylic adhesiveAccelerated conditionPenetration enhancer |
| spellingShingle | Rabinarayan Parhi Suresh Padilam In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin Bulletin of Faculty of Pharmacy Cairo University Simvastatin Drug-in-adhesive patch Acrylic adhesive Accelerated condition Penetration enhancer |
| title | In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin |
| title_full | In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin |
| title_fullStr | In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin |
| title_full_unstemmed | In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin |
| title_short | In vitro permeation and stability studies on developed drug-in-adhesive transdermal patch of simvastatin |
| title_sort | in vitro permeation and stability studies on developed drug in adhesive transdermal patch of simvastatin |
| topic | Simvastatin Drug-in-adhesive patch Acrylic adhesive Accelerated condition Penetration enhancer |
| url | http://www.sciencedirect.com/science/article/pii/S1110093118300097 |
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