Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease
The biological mechanisms underlying the neuropathology of Alzheimer's disease (AD) are complex, as several factors likely contribute to the development of the disease. Therefore, it is not surprising that a number of different possible therapeutic approaches addressing distinct aspects of this...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
2002-01-01
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| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200006 |
| _version_ | 1819145218015887360 |
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| author | DEFELICE FERNANDA G. FERREIRA SÉRGIO T. |
| author_facet | DEFELICE FERNANDA G. FERREIRA SÉRGIO T. |
| author_sort | DEFELICE FERNANDA G. |
| collection | DOAJ |
| description | The biological mechanisms underlying the neuropathology of Alzheimer's disease (AD) are complex, as several factors likely contribute to the development of the disease. Therefore, it is not surprising that a number of different possible therapeutic approaches addressing distinct aspects of this disease are currently being investigated. Among these are ways to prevent amyloid aggregation and/or deposition, to prevent neuronal degeneration, and to increase brain neurotransmitter levels. Here, we discuss possible roles of endogenous modulators of Abeta aggregation in the physiopathology of AD and some of the strategies currently under consideration to interfere with brain levels of beta-amyloid, its aggregation and neurotoxicity. |
| first_indexed | 2024-12-22T12:54:32Z |
| format | Article |
| id | doaj.art-09db83b6a13f4afabda0a448818bc089 |
| institution | Directory Open Access Journal |
| issn | 0001-3765 1678-2690 |
| language | English |
| last_indexed | 2024-12-22T12:54:32Z |
| publishDate | 2002-01-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-09db83b6a13f4afabda0a448818bc0892022-12-21T18:25:09ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências0001-37651678-26902002-01-01742265284Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's diseaseDEFELICE FERNANDA G.FERREIRA SÉRGIO T.The biological mechanisms underlying the neuropathology of Alzheimer's disease (AD) are complex, as several factors likely contribute to the development of the disease. Therefore, it is not surprising that a number of different possible therapeutic approaches addressing distinct aspects of this disease are currently being investigated. Among these are ways to prevent amyloid aggregation and/or deposition, to prevent neuronal degeneration, and to increase brain neurotransmitter levels. Here, we discuss possible roles of endogenous modulators of Abeta aggregation in the physiopathology of AD and some of the strategies currently under consideration to interfere with brain levels of beta-amyloid, its aggregation and neurotoxicity.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200006Alzheimer's diseaseAbeta peptideaggregationneurotoxicityphysiopathological modulators |
| spellingShingle | DEFELICE FERNANDA G. FERREIRA SÉRGIO T. Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease Anais da Academia Brasileira de Ciências Alzheimer's disease Abeta peptide aggregation neurotoxicity physiopathological modulators |
| title | Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease |
| title_full | Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease |
| title_fullStr | Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease |
| title_full_unstemmed | Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease |
| title_short | Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease |
| title_sort | physiopathological modulators of amyloid aggregation and novel pharmacological approaches in alzheimer s disease |
| topic | Alzheimer's disease Abeta peptide aggregation neurotoxicity physiopathological modulators |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200006 |
| work_keys_str_mv | AT defelicefernandag physiopathologicalmodulatorsofamyloidaggregationandnovelpharmacologicalapproachesinalzheimersdisease AT ferreirasergiot physiopathologicalmodulatorsofamyloidaggregationandnovelpharmacologicalapproachesinalzheimersdisease |