Comparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated Gastritis
BACKGROUND: Helicobacter pylori is a non-invasive microorganism causing intense gastric mucosal inflammatory and immune reaction. The gastric mucosal levels of the proinflammatory cytokines Interleukin 6 (IL-6) and IL-8 have been reported to be increased in H. pylori infection, but the serum levels...
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| Format: | Article |
| Language: | English |
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Secretariat of The Indonesian Biomedical Journal
2014-12-01
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| Series: | Indonesian Biomedical Journal |
| Online Access: | http://inabj.org/index.php/ibj/article/view/29 |
| _version_ | 1811333176434360320 |
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| author | Gontar Alamsyah Siregar Sahat Salim Ricky Rivalino Sitepu |
| author_facet | Gontar Alamsyah Siregar Sahat Salim Ricky Rivalino Sitepu |
| author_sort | Gontar Alamsyah Siregar |
| collection | DOAJ |
| description | BACKGROUND: Helicobacter pylori is a non-invasive microorganism causing intense gastric mucosal inflammatory and immune reaction. The gastric mucosal levels of the proinflammatory cytokines Interleukin 6 (IL-6) and IL-8 have been reported to be increased in H. pylori infection, but the serum levels in H. pylori infection is still controversial. The purpose of this study was to investigate the serum levels of IL-6 and IL-8 in H. pylori infection. METHODS: A cross sectional study was done on eighty consecutive gastritis patients admitted to endoscopy units at Adam Malik General Hospital and Permata Bunda Hospital, Medan, Indonesia from May-October 2014. Histopathology was performed for the diagnosis of gastritis. Rapid urease test for diagnosis of H. pylori infection. Serum samples were obtained to determine circulating IL-6 and IL-8. Univariate and bivariate analysis (independent t test) were done. RESULTS: There were 41.25% patients infected with H. pylori. Circulatory IL-6 levels were significantly higher in H. pylori-infected patients compared to H. pylori negative, but there were no differences between serum levels of IL-8 in H. pylori positive and negative patients. CONCLUSIONS: The immune response to H. pylori promotes systemic inflammation, which was reflected in an increased level of serum IL-6. Serum levels of IL-8 were not significantly different between H. pylori positive and negative. KEYWORDS: Helicobacter pylori, gastritis, IL-6, IL-8, cytokine. |
| first_indexed | 2024-04-13T16:48:57Z |
| format | Article |
| id | doaj.art-09dbba5610894202a009acc3a252bd4d |
| institution | Directory Open Access Journal |
| issn | 2085-3297 2355-9179 |
| language | English |
| last_indexed | 2024-04-13T16:48:57Z |
| publishDate | 2014-12-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj.art-09dbba5610894202a009acc3a252bd4d2022-12-22T02:39:00ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792014-12-0163163610.18585/inabj.v6i3.2920Comparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated GastritisGontar Alamsyah Siregar0Sahat Salim1Ricky Rivalino Sitepu2Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatera Utara Jl. Bunga Lau No.17, MedanDepartment of Internal Medicine, Faculty of Medicine, University of Sumatera Utara Jl. Bunga Lau No.17, MedanDepartment of Internal Medicine, Faculty of Medicine, University of Sumatera Utara Jl. Bunga Lau No.17, MedanBACKGROUND: Helicobacter pylori is a non-invasive microorganism causing intense gastric mucosal inflammatory and immune reaction. The gastric mucosal levels of the proinflammatory cytokines Interleukin 6 (IL-6) and IL-8 have been reported to be increased in H. pylori infection, but the serum levels in H. pylori infection is still controversial. The purpose of this study was to investigate the serum levels of IL-6 and IL-8 in H. pylori infection. METHODS: A cross sectional study was done on eighty consecutive gastritis patients admitted to endoscopy units at Adam Malik General Hospital and Permata Bunda Hospital, Medan, Indonesia from May-October 2014. Histopathology was performed for the diagnosis of gastritis. Rapid urease test for diagnosis of H. pylori infection. Serum samples were obtained to determine circulating IL-6 and IL-8. Univariate and bivariate analysis (independent t test) were done. RESULTS: There were 41.25% patients infected with H. pylori. Circulatory IL-6 levels were significantly higher in H. pylori-infected patients compared to H. pylori negative, but there were no differences between serum levels of IL-8 in H. pylori positive and negative patients. CONCLUSIONS: The immune response to H. pylori promotes systemic inflammation, which was reflected in an increased level of serum IL-6. Serum levels of IL-8 were not significantly different between H. pylori positive and negative. KEYWORDS: Helicobacter pylori, gastritis, IL-6, IL-8, cytokine.http://inabj.org/index.php/ibj/article/view/29 |
| spellingShingle | Gontar Alamsyah Siregar Sahat Salim Ricky Rivalino Sitepu Comparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated Gastritis Indonesian Biomedical Journal |
| title | Comparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated Gastritis |
| title_full | Comparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated Gastritis |
| title_fullStr | Comparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated Gastritis |
| title_full_unstemmed | Comparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated Gastritis |
| title_short | Comparison of IL-6, IL-8 Concentrations in H. pylori- and non-H. pylori-associated Gastritis |
| title_sort | comparison of il 6 il 8 concentrations in h pylori and non h pylori associated gastritis |
| url | http://inabj.org/index.php/ibj/article/view/29 |
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