Intravenous Morphine vs Intravenous Ketofol for Treating Renal Colic; a Randomized Controlled Trial
<p><strong>Introduction:</strong> The main purpose of emergency department (ED) management for renal colic is prompt pain relief. The present study aimed to compare the analgesic effects of intravenus (IV) ketofol with morphine in management of ketorolac persistent renal colic. Me...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shahid Beheshti University of Medical Sciences
2016-08-01
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| Series: | Emergency |
| Subjects: | |
| Online Access: | http://journals.sbmu.ac.ir/emergency/article/view/10542 |
| _version_ | 1818335196126117888 |
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| author | Gholamreza Faridaalaee Neda Mohammadi Seyedeh Zahra Merghati Fatemeh Keyghobadi Khajeh Bahman Naghipour Mahboob Pouraghaei Sajjad Ahmadi |
| author_facet | Gholamreza Faridaalaee Neda Mohammadi Seyedeh Zahra Merghati Fatemeh Keyghobadi Khajeh Bahman Naghipour Mahboob Pouraghaei Sajjad Ahmadi |
| author_sort | Gholamreza Faridaalaee |
| collection | DOAJ |
| description | <p><strong>Introduction:</strong> The main purpose of emergency department (ED) management for renal colic is prompt pain relief. The present study aimed to compare the analgesic effects of intravenus (IV) ketofol with morphine in management of ketorolac persistent renal colic. Methods: This study is a single blind randomized, clinical trial, on patients who were presented to ED with renal colic, whose pain was resistant to 30 mg IV ketorolac. The patients were randomly assigned to either IV morphine (0.1 mg/kg) or IV ketofol (0.75 mg/kg propofol and 0.75 mg/kg) and the measures of treatment efficacy were compared between the groups after 5 and 10 minutes. <strong>Results:</strong> 90 patients with mean age of 38.01 ± 9.78 years were randomly divided into 2 groups of 45 (66.7% male). Treatment failure rate was significantly lower in ketofol group after 5 (20% vs 62.2%, p < 0.001) and 10 minutes (11.1% vs 44.4%, p < 0.001). ARR and NNT for ketofol after 5 miutes were 42.22% (95% CI: 23.86 – 60.59) and 3 (95% CI: 1.7 - 4.2), respectively. After 10 minutes, these measures reached 33.33 (95% CI:16.16 – 50.51) and 4 (95% CI: 2.0 - 6.2), respectively. NNH and ARI for hallucination or agitation were 12 (95%CI: 5.8 - 174.2) and 8.89% (0.57 - 17.20), respectively. <strong>Conclusion:</strong> The results of the present study, showed the significant superiority of ketofol (NNT at 5 minute = 3 and NNT at 10 minute = 4) in ketorolac resistant renal colic pain management. However, its NNH of 12, could limit its routine application in ED for this purpose.</p> |
| first_indexed | 2024-12-13T14:19:35Z |
| format | Article |
| id | doaj.art-09dd2ac95055469ba621b6604b8cdf37 |
| institution | Directory Open Access Journal |
| issn | 2345-4563 2345-4571 |
| language | English |
| last_indexed | 2024-12-13T14:19:35Z |
| publishDate | 2016-08-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Emergency |
| spelling | doaj.art-09dd2ac95055469ba621b6604b8cdf372022-12-21T23:42:08ZengShahid Beheshti University of Medical SciencesEmergency2345-45632345-45712016-08-01442022065971Intravenous Morphine vs Intravenous Ketofol for Treating Renal Colic; a Randomized Controlled TrialGholamreza Faridaalaee0Neda Mohammadi1Seyedeh Zahra Merghati2Fatemeh Keyghobadi Khajeh3Bahman Naghipour4Mahboob Pouraghaei5Sajjad Ahmadi6Emergency Medicine Department, Maragheh University of Medical Sciences, Maragheh, IranUrmia University of Medical Sciences, Urmia, IranInternational branch of Urmia University of Medical Sciences, Urmia, IR IranDepartment of Community Medicine, Tabriz University of Medical Sciences, Tabriz, IranAnesthesiology Department, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Emergency Medicine, Tabriz University of Medical Sciences, Tabriz, IranEmergency Medicine Department, Maragheh University of Medical Sciences, Maragheh, Iran<p><strong>Introduction:</strong> The main purpose of emergency department (ED) management for renal colic is prompt pain relief. The present study aimed to compare the analgesic effects of intravenus (IV) ketofol with morphine in management of ketorolac persistent renal colic. Methods: This study is a single blind randomized, clinical trial, on patients who were presented to ED with renal colic, whose pain was resistant to 30 mg IV ketorolac. The patients were randomly assigned to either IV morphine (0.1 mg/kg) or IV ketofol (0.75 mg/kg propofol and 0.75 mg/kg) and the measures of treatment efficacy were compared between the groups after 5 and 10 minutes. <strong>Results:</strong> 90 patients with mean age of 38.01 ± 9.78 years were randomly divided into 2 groups of 45 (66.7% male). Treatment failure rate was significantly lower in ketofol group after 5 (20% vs 62.2%, p < 0.001) and 10 minutes (11.1% vs 44.4%, p < 0.001). ARR and NNT for ketofol after 5 miutes were 42.22% (95% CI: 23.86 – 60.59) and 3 (95% CI: 1.7 - 4.2), respectively. After 10 minutes, these measures reached 33.33 (95% CI:16.16 – 50.51) and 4 (95% CI: 2.0 - 6.2), respectively. NNH and ARI for hallucination or agitation were 12 (95%CI: 5.8 - 174.2) and 8.89% (0.57 - 17.20), respectively. <strong>Conclusion:</strong> The results of the present study, showed the significant superiority of ketofol (NNT at 5 minute = 3 and NNT at 10 minute = 4) in ketorolac resistant renal colic pain management. However, its NNH of 12, could limit its routine application in ED for this purpose.</p>http://journals.sbmu.ac.ir/emergency/article/view/10542Renal colicpainmorphinepropofolketamine |
| spellingShingle | Gholamreza Faridaalaee Neda Mohammadi Seyedeh Zahra Merghati Fatemeh Keyghobadi Khajeh Bahman Naghipour Mahboob Pouraghaei Sajjad Ahmadi Intravenous Morphine vs Intravenous Ketofol for Treating Renal Colic; a Randomized Controlled Trial Emergency Renal colic pain morphine propofol ketamine |
| title | Intravenous Morphine vs Intravenous Ketofol for Treating Renal Colic; a Randomized Controlled Trial |
| title_full | Intravenous Morphine vs Intravenous Ketofol for Treating Renal Colic; a Randomized Controlled Trial |
| title_fullStr | Intravenous Morphine vs Intravenous Ketofol for Treating Renal Colic; a Randomized Controlled Trial |
| title_full_unstemmed | Intravenous Morphine vs Intravenous Ketofol for Treating Renal Colic; a Randomized Controlled Trial |
| title_short | Intravenous Morphine vs Intravenous Ketofol for Treating Renal Colic; a Randomized Controlled Trial |
| title_sort | intravenous morphine vs intravenous ketofol for treating renal colic a randomized controlled trial |
| topic | Renal colic pain morphine propofol ketamine |
| url | http://journals.sbmu.ac.ir/emergency/article/view/10542 |
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