Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

Granzymes A and K are two highly homologous serine proteases expressed by mammalian cytotoxic T cells (CTL) and natural killer cells (NK). Granzyme A is the most abundant of the different granzymes (gzms) expressed by these two cell types. Gzms A and K are found in all jawed vertebrates and are the...

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Bibliographic Details
Main Authors: Erdem Aybay, Jinhye Ryu, Zhirong Fu, Srinivas Akula, Erika Mendez Enriquez, Jenny Hallgren, Sara Wernersson, Anna-Karin Olsson, Lars Hellman
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
cytotoxic T Cells
NK cell
granzyme
apoptosis
caspase
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1211295/full

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