Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles
Objective: To detect the role of endothelial progenitor cells (EPCs) treated with platelet microparticles (PMPs) in preeclampsia. Methods: EPCs treated with/without PMPs were labeled and injected to PE rats. The differentiation of EPCs, the change of endothelial nitric oxide synthase (eNOS), blood p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-10-01
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| Series: | Hypertension in Pregnancy |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641955.2020.1833914 |
| _version_ | 1797633690724990976 |
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| author | Zhenya Fang Anna Li Yaqiong Sun Xietong Wang Meihua Zhang |
| author_facet | Zhenya Fang Anna Li Yaqiong Sun Xietong Wang Meihua Zhang |
| author_sort | Zhenya Fang |
| collection | DOAJ |
| description | Objective: To detect the role of endothelial progenitor cells (EPCs) treated with platelet microparticles (PMPs) in preeclampsia. Methods: EPCs treated with/without PMPs were labeled and injected to PE rats. The differentiation of EPCs, the change of endothelial nitric oxide synthase (eNOS), blood pressure and proteinuria were measured. The blood pressure and proteinuria increased in each of PE groups, and were improved by EPCs which was strengthened by PMPs. Transplantation of EPCs increased placental angiogenesis. The trend of change of NO was the same as blood pressure. Conclusion: Transplantation of EPCs treated with PMPs improved blood pressure and proteinuria more effectively. |
| first_indexed | 2024-03-11T11:57:25Z |
| format | Article |
| id | doaj.art-09e16ed77f7c4c1cbf615b9f773e9d70 |
| institution | Directory Open Access Journal |
| issn | 1064-1955 1525-6065 |
| language | English |
| last_indexed | 2024-03-11T11:57:25Z |
| publishDate | 2020-10-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hypertension in Pregnancy |
| spelling | doaj.art-09e16ed77f7c4c1cbf615b9f773e9d702023-11-08T11:49:22ZengTaylor & Francis GroupHypertension in Pregnancy1064-19551525-60652020-10-0139446147010.1080/10641955.2020.18339141833914Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticlesZhenya Fang0Anna Li1Yaqiong Sun2Xietong Wang3Meihua Zhang4Shandong Maternal and Child Health Care HospitalShandong Maternal and Child Health Care HospitalShandong Maternal and Child Health Care HospitalShandong Maternal and Child Health Care HospitalShandong Maternal and Child Health Care HospitalObjective: To detect the role of endothelial progenitor cells (EPCs) treated with platelet microparticles (PMPs) in preeclampsia. Methods: EPCs treated with/without PMPs were labeled and injected to PE rats. The differentiation of EPCs, the change of endothelial nitric oxide synthase (eNOS), blood pressure and proteinuria were measured. The blood pressure and proteinuria increased in each of PE groups, and were improved by EPCs which was strengthened by PMPs. Transplantation of EPCs increased placental angiogenesis. The trend of change of NO was the same as blood pressure. Conclusion: Transplantation of EPCs treated with PMPs improved blood pressure and proteinuria more effectively.http://dx.doi.org/10.1080/10641955.2020.1833914platelet microparticlesendothelial progenitor cellspreeclampsiaendothelial nitric oxide synthase |
| spellingShingle | Zhenya Fang Anna Li Yaqiong Sun Xietong Wang Meihua Zhang Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles Hypertension in Pregnancy platelet microparticles endothelial progenitor cells preeclampsia endothelial nitric oxide synthase |
| title | Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles |
| title_full | Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles |
| title_fullStr | Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles |
| title_full_unstemmed | Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles |
| title_short | Improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles |
| title_sort | improved placental vascular repair in a rat preeclampsia model by implantation of endothelial progenitor cells treated with platelet microparticles |
| topic | platelet microparticles endothelial progenitor cells preeclampsia endothelial nitric oxide synthase |
| url | http://dx.doi.org/10.1080/10641955.2020.1833914 |
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