Arachidonic acid intake and asthma risk in children and adults: a systematic review of observational studies
The effect of arachidonic acid (ARA) intake on asthma risk is unclear. The objective of the present review was to systematically evaluate available observational studies on the relationship between ARA exposure and asthma risk in children and adults. A PubMed search was conducted on 22 October 2013...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2014-01-01
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| Series: | Journal of Nutritional Science |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679014000093/type/journal_article |
| _version_ | 1811155964008595456 |
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| author | Saki Kakutani Kahori Egawa Kayo Saito Toshihide Suzuki Chika Horikawa Tomohiro Rogi Hiroshi Kawashima Hiroshi Shibata Satoshi Sasaki |
| author_facet | Saki Kakutani Kahori Egawa Kayo Saito Toshihide Suzuki Chika Horikawa Tomohiro Rogi Hiroshi Kawashima Hiroshi Shibata Satoshi Sasaki |
| author_sort | Saki Kakutani |
| collection | DOAJ |
| description | The effect of arachidonic acid (ARA) intake on asthma risk is unclear. The objective of the present review was to systematically evaluate available observational studies on the relationship between ARA exposure and asthma risk in children and adults. A PubMed search was conducted on 22 October 2013 and seventy-three publications were checked against predefined criteria for eligibility. To identify additional eligible publications, potentially relevant articles were searched from bibliographies of articles on ARA and asthma. A total of 2924 citations were scrutinised. Finally, fourteen articles were included. A quality assessment was conducted based on the reporting and methodological quality. A meta-analysis was not conducted; therefore, a qualitative assessment is presented. Three high-, two medium- and ten low-quality studies were reviewed. Eleven studies, including two high- and two medium-quality studies, did not find a significant association between ARA exposure and asthma risk. In contrast, one high-quality study indicated a significant trend toward reducing asthma risk in children with decreasing maternal ARA intake (P
trend = 0·025), and one low-quality study reported a significant trend of increasing asthma risk with higher blood ARA levels (P
trend = 0·007). In two low-quality studies, asthma patients had significantly lower blood ARA levels than controls (both P < 0·05). These studies did not sufficiently demonstrate any relationships between ARA exposure and asthma risk because of the limited number of studies and their methodological limitations. They seem to suggest that ARA exposure is not consistently associated with asthma risk. Nevertheless, further evidence is required to prove or disprove the association. |
| first_indexed | 2024-04-10T04:43:37Z |
| format | Article |
| id | doaj.art-09e5729bf26d4af5b1145cb40f61d856 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:43:37Z |
| publishDate | 2014-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-09e5729bf26d4af5b1145cb40f61d8562023-03-09T12:38:43ZengCambridge University PressJournal of Nutritional Science2048-67902014-01-01310.1017/jns.2014.9Arachidonic acid intake and asthma risk in children and adults: a systematic review of observational studiesSaki Kakutani0Kahori Egawa1Kayo Saito2Toshihide Suzuki3Chika Horikawa4Tomohiro Rogi5Hiroshi Kawashima6Hiroshi Shibata7Satoshi Sasaki8Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, Japan Institute for Health Care Science, Suntory Wellness Limited, Osaka, JapanInstitute for Health Care Science, Suntory Wellness Limited, Osaka, JapanInstitute for Health Care Science, Suntory Wellness Limited, Osaka, JapanInstitute for Health Care Science, Suntory Wellness Limited, Osaka, JapanInstitute for Health Care Science, Suntory Wellness Limited, Osaka, JapanInstitute for Health Care Science, Suntory Wellness Limited, Osaka, JapanInstitute for Health Care Science, Suntory Wellness Limited, Osaka, JapanInstitute for Health Care Science, Suntory Wellness Limited, Osaka, JapanDepartment of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Tokyo, JapanThe effect of arachidonic acid (ARA) intake on asthma risk is unclear. The objective of the present review was to systematically evaluate available observational studies on the relationship between ARA exposure and asthma risk in children and adults. A PubMed search was conducted on 22 October 2013 and seventy-three publications were checked against predefined criteria for eligibility. To identify additional eligible publications, potentially relevant articles were searched from bibliographies of articles on ARA and asthma. A total of 2924 citations were scrutinised. Finally, fourteen articles were included. A quality assessment was conducted based on the reporting and methodological quality. A meta-analysis was not conducted; therefore, a qualitative assessment is presented. Three high-, two medium- and ten low-quality studies were reviewed. Eleven studies, including two high- and two medium-quality studies, did not find a significant association between ARA exposure and asthma risk. In contrast, one high-quality study indicated a significant trend toward reducing asthma risk in children with decreasing maternal ARA intake (P trend = 0·025), and one low-quality study reported a significant trend of increasing asthma risk with higher blood ARA levels (P trend = 0·007). In two low-quality studies, asthma patients had significantly lower blood ARA levels than controls (both P < 0·05). These studies did not sufficiently demonstrate any relationships between ARA exposure and asthma risk because of the limited number of studies and their methodological limitations. They seem to suggest that ARA exposure is not consistently associated with asthma risk. Nevertheless, further evidence is required to prove or disprove the association.https://www.cambridge.org/core/product/identifier/S2048679014000093/type/journal_articleEpidemiologyAsthmaDietary fatty acidsFree-living populations |
| spellingShingle | Saki Kakutani Kahori Egawa Kayo Saito Toshihide Suzuki Chika Horikawa Tomohiro Rogi Hiroshi Kawashima Hiroshi Shibata Satoshi Sasaki Arachidonic acid intake and asthma risk in children and adults: a systematic review of observational studies Journal of Nutritional Science Epidemiology Asthma Dietary fatty acids Free-living populations |
| title | Arachidonic acid intake and asthma risk in children and adults: a systematic review of observational studies |
| title_full | Arachidonic acid intake and asthma risk in children and adults: a systematic review of observational studies |
| title_fullStr | Arachidonic acid intake and asthma risk in children and adults: a systematic review of observational studies |
| title_full_unstemmed | Arachidonic acid intake and asthma risk in children and adults: a systematic review of observational studies |
| title_short | Arachidonic acid intake and asthma risk in children and adults: a systematic review of observational studies |
| title_sort | arachidonic acid intake and asthma risk in children and adults a systematic review of observational studies |
| topic | Epidemiology Asthma Dietary fatty acids Free-living populations |
| url | https://www.cambridge.org/core/product/identifier/S2048679014000093/type/journal_article |
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