Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria
Aotus is one of the WHO-recommended primate models for studies in malaria, and several species can be infected with Plasmodium falciparum or P. vivax. Here we describe the successful infection of the species A. infulatus from eastern Amazon with blood stages of P. falciparum. Both intact and splenec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2000-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000300011 |
| _version_ | 1797703155726680064 |
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| author | Carvalho Leonardo JM Oliveira Salma G Alves Francisco A Brígido Maria CO Muniz José APC Daniel-Ribeiro Claudio T |
| author_facet | Carvalho Leonardo JM Oliveira Salma G Alves Francisco A Brígido Maria CO Muniz José APC Daniel-Ribeiro Claudio T |
| author_sort | Carvalho Leonardo JM |
| collection | DOAJ |
| description | Aotus is one of the WHO-recommended primate models for studies in malaria, and several species can be infected with Plasmodium falciparum or P. vivax. Here we describe the successful infection of the species A. infulatus from eastern Amazon with blood stages of P. falciparum. Both intact and splenectomized animals were susceptible to infection; the intact ones were able to keep parasitemias at lower levels for several days, but developed complications such as severe anemia; splenectomized monkeys developed higher parasitemias but no major complications. We conclude that A. infulatus is susceptible to P. falciparum infection and may represent an alternative model for studies in malaria. |
| first_indexed | 2024-03-12T05:01:24Z |
| format | Article |
| id | doaj.art-09e7d5c622514ed8b0db7d8a3267f0fc |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:01:24Z |
| publishDate | 2000-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-09e7d5c622514ed8b0db7d8a3267f0fc2023-09-03T09:11:23ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602000-01-01953363365Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malariaCarvalho Leonardo JMOliveira Salma GAlves Francisco ABrígido Maria COMuniz José APCDaniel-Ribeiro Claudio TAotus is one of the WHO-recommended primate models for studies in malaria, and several species can be infected with Plasmodium falciparum or P. vivax. Here we describe the successful infection of the species A. infulatus from eastern Amazon with blood stages of P. falciparum. Both intact and splenectomized animals were susceptible to infection; the intact ones were able to keep parasitemias at lower levels for several days, but developed complications such as severe anemia; splenectomized monkeys developed higher parasitemias but no major complications. We conclude that A. infulatus is susceptible to P. falciparum infection and may represent an alternative model for studies in malaria.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000300011Aotus infulatusPlasmodium falciparummalariaprimate model |
| spellingShingle | Carvalho Leonardo JM Oliveira Salma G Alves Francisco A Brígido Maria CO Muniz José APC Daniel-Ribeiro Claudio T Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria Memorias do Instituto Oswaldo Cruz Aotus infulatus Plasmodium falciparum malaria primate model |
| title | Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria |
| title_full | Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria |
| title_fullStr | Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria |
| title_full_unstemmed | Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria |
| title_short | Aotus infulatus monkey is susceptible to Plasmodium falciparum infection and may constitute an alternative experimental model for malaria |
| title_sort | aotus infulatus monkey is susceptible to plasmodium falciparum infection and may constitute an alternative experimental model for malaria |
| topic | Aotus infulatus Plasmodium falciparum malaria primate model |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762000000300011 |
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