Right Dorsolateral Frontal Lobe N-Acetyl Aspartate and Myoinositol Concentration Estimation in Type 2 Diabetes with Magnetic Resonance Spectroscopy
Introduction: Chronic hyperglycaemia in type 2 diabetes, effects the central nervous system by altering the concentrations of brain metabolites like N-acetyl aspartate (NAA) and myoinositol (mI), which are indicators of neuronal integrity and glial cell damage respectively. Dorsolateral frontal...
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JCDR Research and Publications Private Limited
2015-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/6234/14153_CE[Ra1]_F(AK)_PF1(PAK)_PFA(P)_PF2(PAG).pdf |
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| author | Rajani Santhakumari Nagothu Yogananda Reddy Indla Archana Rajagopalan Ravi Varma |
| author_facet | Rajani Santhakumari Nagothu Yogananda Reddy Indla Archana Rajagopalan Ravi Varma |
| author_sort | Rajani Santhakumari Nagothu |
| collection | DOAJ |
| description | Introduction: Chronic hyperglycaemia in type 2 diabetes, effects
the central nervous system by altering the concentrations of brain
metabolites like N-acetyl aspartate (NAA) and myoinositol (mI),
which are indicators of neuronal integrity and glial cell damage
respectively. Dorsolateral frontal lobe is associated with aspects
of cognition especially right frontal lobe is involved in episodic
memory retrieval, ninety percent of the diabetic cases are type
2 in nature globally and yoga is very effective in stabilizing the
brain metabolites by bringing the blood glucose levels to near
or within the physiological range in type 2 diabetes.
Aim and Objectives: The aim of the study was to observe the
effects of yogasana and pranayama on glycosilated haemoglobin
(HbA1c) levels and right dorsolateral frontal cortical NAA and mI
concentration in type 2 diabetic subjects.
Materials and Methods: It’s a case control study. Sixty eight
type 2 diabetic subjects of both the sex, aged between 35-
65 years are included in the study, subjects are divided in to
test and control group 34 each. Test group subjects did the
yogasana and pranayama for a period of 6 months, 6 days
in a week, 45-60 minutes daily under the supervision of a
qualified yoga teacher. Control group subjects are not on any
specific exercise regimen. Both the group subjects are taking
oral hypoglycaemic agents. HbA1c levels are measured using
the Bio-Rad D-10™ haemoglobin A1c program and Magnetic
Resonance Spectroscopy (MRS) is used in assessing the
metabolite concentrations.
Statistical analysis: Analysis of data was done by using
unpaired t-test. P-value for HbA1c level is <0.001, which is
highly significant statistically. P-value for NAA was < 0.02 and
for myoinositol was < 0.01, which are statistically significant.
Results : HbA1c levels in control and test group subjects are
7.7 ± 1.84 and 6.02 ± 0.46 respectively. NAA concentrations in
the right dorsolateral frontal lobe of control and test group are
1.44 ± 0.15 and 1.54 ± 0.19 respectively. The mI concentrations
in the right dorsolateral frontal lobe of control and test group are
0.61 ± 0.22 and 0.47 ± 0.24 respectively.
Conclusion: Yogasana and pranayama minimized the neuronal
and glial cellular damage in test group, which is evident by
minimal changes in right dorsolateral frontal lobe NAA and mI
levels in type 2 diabetic subjects. |
| first_indexed | 2024-12-22T01:51:44Z |
| format | Article |
| id | doaj.art-09e87a7714d64661b342d50f90d1ecd0 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-22T01:51:44Z |
| publishDate | 2015-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-09e87a7714d64661b342d50f90d1ecd02022-12-21T18:42:54ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-07-0197CC16CC1910.7860/JCDR/2015/14153.6234Right Dorsolateral Frontal Lobe N-Acetyl Aspartate and Myoinositol Concentration Estimation in Type 2 Diabetes with Magnetic Resonance SpectroscopyRajani Santhakumari Nagothu0Yogananda Reddy Indla1Archana Rajagopalan2Ravi Varma3Assistant Professor, Department of Physiology, MediCiti Institute of Medical Sciences, Hyderabad, India.Associate Professor, Department of Physiology, MediCiti Institute of Medical Sciences, Hyderabad, India.Professor, Department of Physiology, Saveetha Medical college, Chennai, India.Professor, Department of Radiology, MediCiti Institute of Medical Sciences, Hyderabad, India.Introduction: Chronic hyperglycaemia in type 2 diabetes, effects the central nervous system by altering the concentrations of brain metabolites like N-acetyl aspartate (NAA) and myoinositol (mI), which are indicators of neuronal integrity and glial cell damage respectively. Dorsolateral frontal lobe is associated with aspects of cognition especially right frontal lobe is involved in episodic memory retrieval, ninety percent of the diabetic cases are type 2 in nature globally and yoga is very effective in stabilizing the brain metabolites by bringing the blood glucose levels to near or within the physiological range in type 2 diabetes. Aim and Objectives: The aim of the study was to observe the effects of yogasana and pranayama on glycosilated haemoglobin (HbA1c) levels and right dorsolateral frontal cortical NAA and mI concentration in type 2 diabetic subjects. Materials and Methods: It’s a case control study. Sixty eight type 2 diabetic subjects of both the sex, aged between 35- 65 years are included in the study, subjects are divided in to test and control group 34 each. Test group subjects did the yogasana and pranayama for a period of 6 months, 6 days in a week, 45-60 minutes daily under the supervision of a qualified yoga teacher. Control group subjects are not on any specific exercise regimen. Both the group subjects are taking oral hypoglycaemic agents. HbA1c levels are measured using the Bio-Rad D-10™ haemoglobin A1c program and Magnetic Resonance Spectroscopy (MRS) is used in assessing the metabolite concentrations. Statistical analysis: Analysis of data was done by using unpaired t-test. P-value for HbA1c level is <0.001, which is highly significant statistically. P-value for NAA was < 0.02 and for myoinositol was < 0.01, which are statistically significant. Results : HbA1c levels in control and test group subjects are 7.7 ± 1.84 and 6.02 ± 0.46 respectively. NAA concentrations in the right dorsolateral frontal lobe of control and test group are 1.44 ± 0.15 and 1.54 ± 0.19 respectively. The mI concentrations in the right dorsolateral frontal lobe of control and test group are 0.61 ± 0.22 and 0.47 ± 0.24 respectively. Conclusion: Yogasana and pranayama minimized the neuronal and glial cellular damage in test group, which is evident by minimal changes in right dorsolateral frontal lobe NAA and mI levels in type 2 diabetic subjects.https://jcdr.net/articles/PDF/6234/14153_CE[Ra1]_F(AK)_PF1(PAK)_PFA(P)_PF2(PAG).pdffrontal lobeglycosilated haemoglobinyogasana and pranayama |
| spellingShingle | Rajani Santhakumari Nagothu Yogananda Reddy Indla Archana Rajagopalan Ravi Varma Right Dorsolateral Frontal Lobe N-Acetyl Aspartate and Myoinositol Concentration Estimation in Type 2 Diabetes with Magnetic Resonance Spectroscopy Journal of Clinical and Diagnostic Research frontal lobe glycosilated haemoglobin yogasana and pranayama |
| title | Right Dorsolateral Frontal Lobe N-Acetyl Aspartate and Myoinositol Concentration Estimation in Type 2 Diabetes with Magnetic Resonance Spectroscopy |
| title_full | Right Dorsolateral Frontal Lobe N-Acetyl Aspartate and Myoinositol Concentration Estimation in Type 2 Diabetes with Magnetic Resonance Spectroscopy |
| title_fullStr | Right Dorsolateral Frontal Lobe N-Acetyl Aspartate and Myoinositol Concentration Estimation in Type 2 Diabetes with Magnetic Resonance Spectroscopy |
| title_full_unstemmed | Right Dorsolateral Frontal Lobe N-Acetyl Aspartate and Myoinositol Concentration Estimation in Type 2 Diabetes with Magnetic Resonance Spectroscopy |
| title_short | Right Dorsolateral Frontal Lobe N-Acetyl Aspartate and Myoinositol Concentration Estimation in Type 2 Diabetes with Magnetic Resonance Spectroscopy |
| title_sort | right dorsolateral frontal lobe n acetyl aspartate and myoinositol concentration estimation in type 2 diabetes with magnetic resonance spectroscopy |
| topic | frontal lobe glycosilated haemoglobin yogasana and pranayama |
| url | https://jcdr.net/articles/PDF/6234/14153_CE[Ra1]_F(AK)_PF1(PAK)_PFA(P)_PF2(PAG).pdf |
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