Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users
David J Browning,1 Chong Lee2 1Charlotte Eye, Ear, Nose and Throat Associates, 2University of North Carolina – Charlotte, Charlotte, NC, USA Purpose: To determine measurement variability of N1P1 amplitudes and the R1/R2 ratio in normal subjects and hydroxychloroquine users without retino...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2014-08-01
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| Series: | Clinical Ophthalmology |
| Online Access: | http://www.dovepress.com/test-retest-variability-of-multifocal-electroretinography-in-normal-vo-peer-reviewed-article-OPTH |
| _version_ | 1818909604444110848 |
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| author | Browning DJ Lee C |
| author_facet | Browning DJ Lee C |
| author_sort | Browning DJ |
| collection | DOAJ |
| description | David J Browning,1 Chong Lee2 1Charlotte Eye, Ear, Nose and Throat Associates, 2University of North Carolina – Charlotte, Charlotte, NC, USA Purpose: To determine measurement variability of N1P1 amplitudes and the R1/R2 ratio in normal subjects and hydroxychloroquine users without retinopathy. Design: Retrospective, observational study. Subjects: Normal subjects (n=21) and 44 patients taking hydroxychloroquine (n=44) without retinopathy. Methods: Multifocal electroretinography (mfERG) was performed twice in one session in the 21 normal subjects and twice within 1 year in the hydroxychloroquine users, during which time no clinical change in macular status occurred. Main outcome measures: N1P1 amplitudes of rings R1–R5, the R1/R2 ratio, and coefficients of repeatability (COR) for these measurements. Results: Values for N1P1 amplitudes in hydroxychloroquine users were reduced compared with normal subjects by the known effect of age, but R1/R2 was not affected by age. The COR for R1–R5 ranged from 43% to 52% for normal subjects and from 43% to 59% for hydroxychloroquine users; for R1/R2 the COR was 29% in normal subjects and 45% in hydroxychloroquine users. Conclusion: mfERG measurements show high test-retest variability, limiting the ability of a single mfERG test to influence a decision to stop hydroxychloroquine; corroborative evidence with a different ancillary test is recommended in a suspicious case. Keywords: multifocal electroretinography, hydroxychloroquine, test-retest variability |
| first_indexed | 2024-12-19T22:29:33Z |
| format | Article |
| id | doaj.art-09e90a6126bd4aca97313e6b8ee6d0f2 |
| institution | Directory Open Access Journal |
| issn | 1177-5483 |
| language | English |
| last_indexed | 2024-12-19T22:29:33Z |
| publishDate | 2014-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Ophthalmology |
| spelling | doaj.art-09e90a6126bd4aca97313e6b8ee6d0f22022-12-21T20:03:22ZengDove Medical PressClinical Ophthalmology1177-54832014-08-012014default1467147317868Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine usersBrowning DJLee CDavid J Browning,1 Chong Lee2 1Charlotte Eye, Ear, Nose and Throat Associates, 2University of North Carolina – Charlotte, Charlotte, NC, USA Purpose: To determine measurement variability of N1P1 amplitudes and the R1/R2 ratio in normal subjects and hydroxychloroquine users without retinopathy. Design: Retrospective, observational study. Subjects: Normal subjects (n=21) and 44 patients taking hydroxychloroquine (n=44) without retinopathy. Methods: Multifocal electroretinography (mfERG) was performed twice in one session in the 21 normal subjects and twice within 1 year in the hydroxychloroquine users, during which time no clinical change in macular status occurred. Main outcome measures: N1P1 amplitudes of rings R1–R5, the R1/R2 ratio, and coefficients of repeatability (COR) for these measurements. Results: Values for N1P1 amplitudes in hydroxychloroquine users were reduced compared with normal subjects by the known effect of age, but R1/R2 was not affected by age. The COR for R1–R5 ranged from 43% to 52% for normal subjects and from 43% to 59% for hydroxychloroquine users; for R1/R2 the COR was 29% in normal subjects and 45% in hydroxychloroquine users. Conclusion: mfERG measurements show high test-retest variability, limiting the ability of a single mfERG test to influence a decision to stop hydroxychloroquine; corroborative evidence with a different ancillary test is recommended in a suspicious case. Keywords: multifocal electroretinography, hydroxychloroquine, test-retest variability http://www.dovepress.com/test-retest-variability-of-multifocal-electroretinography-in-normal-vo-peer-reviewed-article-OPTH |
| spellingShingle | Browning DJ Lee C Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users Clinical Ophthalmology |
| title | Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users |
| title_full | Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users |
| title_fullStr | Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users |
| title_full_unstemmed | Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users |
| title_short | Test-retest variability of multifocal electroretinography in normal volunteers and short-term variability in hydroxychloroquine users |
| title_sort | test retest variability of multifocal electroretinography in normal volunteers and short term variability in hydroxychloroquine users |
| url | http://www.dovepress.com/test-retest-variability-of-multifocal-electroretinography-in-normal-vo-peer-reviewed-article-OPTH |
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