A Systematic Review of <i>Orthosiphon stamineus</i> Benth. in the Treatment of Diabetes and Its Complications
(1) Background: <i>Orthosiphon stamineus</i> Benth. is a traditional medicine used in the treatment of diabetes and chronic renal failure in southern China, Malaysia, and Thailand. Diabetes is a chronic metabolic disease and the number of diabetic patients in the world is increasing. Thi...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/2/444 |
| _version_ | 1797491519554322432 |
|---|---|
| author | Qirou Wang Jia Wang Nannan Li Junyu Liu Jingna Zhou Pengwei Zhuang Haixia Chen |
| author_facet | Qirou Wang Jia Wang Nannan Li Junyu Liu Jingna Zhou Pengwei Zhuang Haixia Chen |
| author_sort | Qirou Wang |
| collection | DOAJ |
| description | (1) Background: <i>Orthosiphon stamineus</i> Benth. is a traditional medicine used in the treatment of diabetes and chronic renal failure in southern China, Malaysia, and Thailand. Diabetes is a chronic metabolic disease and the number of diabetic patients in the world is increasing. This review aimed to systematically review the effects of <i>O. stamineus</i> in the treatment of diabetes and its complications and the pharmacodynamic material basis. (2) Methods: This systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), using the databases ScienceDirect, PubMed, and Web of Science. (3) Results: Thirty-one articles related to <i>O. stamineus</i> and diabetes were included. The mechanisms of <i>O. stamineus</i> in the treatment of diabetes and its complications mainly included inhibiting α-amylase and α-glucosidase activities, antioxidant and anti-inflammatory activities, regulating lipid metabolism, promoting insulin secretion, ameliorating insulin resistance, increasing glucose uptake, promoting glycolysis, inhibiting gluconeogenesis, promoting glucagon-likepeptide-1 (GLP-1) secretion and antiglycation activity. Phenolic acids, flavonoids and triterpenoids might be the main components for hypoglycemia effects in <i>O. stamineus</i>. (4) Conclusion: <i>O. stamineus</i> could be an antidiabetic agent to treat diabetes and its complications. However, it needs further study on a pharmacodynamic substance basis and the mechanisms of effective constituents. |
| first_indexed | 2024-03-10T00:50:35Z |
| format | Article |
| id | doaj.art-09e999cba3e44972a2a458613496099d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T00:50:35Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-09e999cba3e44972a2a458613496099d2023-11-23T14:52:09ZengMDPI AGMolecules1420-30492022-01-0127244410.3390/molecules27020444A Systematic Review of <i>Orthosiphon stamineus</i> Benth. in the Treatment of Diabetes and Its ComplicationsQirou Wang0Jia Wang1Nannan Li2Junyu Liu3Jingna Zhou4Pengwei Zhuang5Haixia Chen6Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, ChinaTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, ChinaHaihe Laboratory of Modern Chinese Medicine, Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, ChinaTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China(1) Background: <i>Orthosiphon stamineus</i> Benth. is a traditional medicine used in the treatment of diabetes and chronic renal failure in southern China, Malaysia, and Thailand. Diabetes is a chronic metabolic disease and the number of diabetic patients in the world is increasing. This review aimed to systematically review the effects of <i>O. stamineus</i> in the treatment of diabetes and its complications and the pharmacodynamic material basis. (2) Methods: This systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), using the databases ScienceDirect, PubMed, and Web of Science. (3) Results: Thirty-one articles related to <i>O. stamineus</i> and diabetes were included. The mechanisms of <i>O. stamineus</i> in the treatment of diabetes and its complications mainly included inhibiting α-amylase and α-glucosidase activities, antioxidant and anti-inflammatory activities, regulating lipid metabolism, promoting insulin secretion, ameliorating insulin resistance, increasing glucose uptake, promoting glycolysis, inhibiting gluconeogenesis, promoting glucagon-likepeptide-1 (GLP-1) secretion and antiglycation activity. Phenolic acids, flavonoids and triterpenoids might be the main components for hypoglycemia effects in <i>O. stamineus</i>. (4) Conclusion: <i>O. stamineus</i> could be an antidiabetic agent to treat diabetes and its complications. However, it needs further study on a pharmacodynamic substance basis and the mechanisms of effective constituents.https://www.mdpi.com/1420-3049/27/2/444<i>Orthosiphon stamineus</i>diabetesdiabetic complicationshypoglycemic activityantidiabetic mechanisms |
| spellingShingle | Qirou Wang Jia Wang Nannan Li Junyu Liu Jingna Zhou Pengwei Zhuang Haixia Chen A Systematic Review of <i>Orthosiphon stamineus</i> Benth. in the Treatment of Diabetes and Its Complications Molecules <i>Orthosiphon stamineus</i> diabetes diabetic complications hypoglycemic activity antidiabetic mechanisms |
| title | A Systematic Review of <i>Orthosiphon stamineus</i> Benth. in the Treatment of Diabetes and Its Complications |
| title_full | A Systematic Review of <i>Orthosiphon stamineus</i> Benth. in the Treatment of Diabetes and Its Complications |
| title_fullStr | A Systematic Review of <i>Orthosiphon stamineus</i> Benth. in the Treatment of Diabetes and Its Complications |
| title_full_unstemmed | A Systematic Review of <i>Orthosiphon stamineus</i> Benth. in the Treatment of Diabetes and Its Complications |
| title_short | A Systematic Review of <i>Orthosiphon stamineus</i> Benth. in the Treatment of Diabetes and Its Complications |
| title_sort | systematic review of i orthosiphon stamineus i benth in the treatment of diabetes and its complications |
| topic | <i>Orthosiphon stamineus</i> diabetes diabetic complications hypoglycemic activity antidiabetic mechanisms |
| url | https://www.mdpi.com/1420-3049/27/2/444 |
| work_keys_str_mv | AT qirouwang asystematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT jiawang asystematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT nannanli asystematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT junyuliu asystematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT jingnazhou asystematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT pengweizhuang asystematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT haixiachen asystematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT qirouwang systematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT jiawang systematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT nannanli systematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT junyuliu systematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT jingnazhou systematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT pengweizhuang systematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications AT haixiachen systematicreviewofiorthosiphonstamineusibenthinthetreatmentofdiabetesanditscomplications |