Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration

Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration

Abstract Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Current problems in the clinic include metastasis, recurrence, and treatment-related sequelae that highlight the need for targeted therapies. Epigenetic perturbations are an established hallmark of human M...

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Bibliographic Details
Main Authors: Keri Callegari, Shinji Maegawa, Javiera Bravo-Alegria, Vidya Gopalakrishnan
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Cell Communication and Signaling
Subjects:
LSD1
REST
SHH
Medulloblastoma
Tranylcypromine
HIF1A
Online Access:http://link.springer.com/article/10.1186/s12964-018-0275-5

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