Bacteria–bacteriophage cycles facilitate Cholera outbreak cycles: an indirect Susceptible-Infected-Recovered-Bacteria- Phage (iSIRBP) model-based mathematical study
Cholera is an acute enteric infectious disease caused by the Gram-negative bacterium Vibrio cholerae. Despite a huge body of research, the precise nature of its transmission dynamics has yet to be fully elucidated. Mathematical models can be useful to better understand how an infectious agent can sp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Journal of Biological Dynamics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/17513758.2021.2017032 |
| _version_ | 1798019735981391872 |
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| author | Asma Al Habees Eman Aldabbas Nicola L. Bragazzi Jude D. Kong |
| author_facet | Asma Al Habees Eman Aldabbas Nicola L. Bragazzi Jude D. Kong |
| author_sort | Asma Al Habees |
| collection | DOAJ |
| description | Cholera is an acute enteric infectious disease caused by the Gram-negative bacterium Vibrio cholerae. Despite a huge body of research, the precise nature of its transmission dynamics has yet to be fully elucidated. Mathematical models can be useful to better understand how an infectious agent can spread and be properly controlled. We develop a compartmental model describing a human population, a bacterial population as well as a phage population. We show that there might be eight equilibrium points, one of which is a disease free equilibrium point. We carry out numerical simulations and sensitivity analyses and we show that the presence of phage can reduce the number of infectious individuals. Moreover, we discuss the main implications in terms of public health management and control strategies. |
| first_indexed | 2024-04-11T16:44:28Z |
| format | Article |
| id | doaj.art-09ef973350804c88a048dee27bf9ca60 |
| institution | Directory Open Access Journal |
| issn | 1751-3758 1751-3766 |
| language | English |
| last_indexed | 2024-04-11T16:44:28Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Biological Dynamics |
| spelling | doaj.art-09ef973350804c88a048dee27bf9ca602022-12-22T04:13:35ZengTaylor & Francis GroupJournal of Biological Dynamics1751-37581751-37662022-12-01161294310.1080/17513758.2021.20170322017032Bacteria–bacteriophage cycles facilitate Cholera outbreak cycles: an indirect Susceptible-Infected-Recovered-Bacteria- Phage (iSIRBP) model-based mathematical studyAsma Al Habees0Eman Aldabbas1Nicola L. Bragazzi2Jude D. Kong3The University of JordanThe University of JordanYork UniversityYork UniversityCholera is an acute enteric infectious disease caused by the Gram-negative bacterium Vibrio cholerae. Despite a huge body of research, the precise nature of its transmission dynamics has yet to be fully elucidated. Mathematical models can be useful to better understand how an infectious agent can spread and be properly controlled. We develop a compartmental model describing a human population, a bacterial population as well as a phage population. We show that there might be eight equilibrium points, one of which is a disease free equilibrium point. We carry out numerical simulations and sensitivity analyses and we show that the presence of phage can reduce the number of infectious individuals. Moreover, we discuss the main implications in terms of public health management and control strategies.http://dx.doi.org/10.1080/17513758.2021.2017032cholerabacteriophagephagebasic reproduction number |
| spellingShingle | Asma Al Habees Eman Aldabbas Nicola L. Bragazzi Jude D. Kong Bacteria–bacteriophage cycles facilitate Cholera outbreak cycles: an indirect Susceptible-Infected-Recovered-Bacteria- Phage (iSIRBP) model-based mathematical study Journal of Biological Dynamics cholera bacteriophage phage basic reproduction number |
| title | Bacteria–bacteriophage cycles facilitate Cholera outbreak cycles: an indirect Susceptible-Infected-Recovered-Bacteria- Phage (iSIRBP) model-based mathematical study |
| title_full | Bacteria–bacteriophage cycles facilitate Cholera outbreak cycles: an indirect Susceptible-Infected-Recovered-Bacteria- Phage (iSIRBP) model-based mathematical study |
| title_fullStr | Bacteria–bacteriophage cycles facilitate Cholera outbreak cycles: an indirect Susceptible-Infected-Recovered-Bacteria- Phage (iSIRBP) model-based mathematical study |
| title_full_unstemmed | Bacteria–bacteriophage cycles facilitate Cholera outbreak cycles: an indirect Susceptible-Infected-Recovered-Bacteria- Phage (iSIRBP) model-based mathematical study |
| title_short | Bacteria–bacteriophage cycles facilitate Cholera outbreak cycles: an indirect Susceptible-Infected-Recovered-Bacteria- Phage (iSIRBP) model-based mathematical study |
| title_sort | bacteria bacteriophage cycles facilitate cholera outbreak cycles an indirect susceptible infected recovered bacteria phage isirbp model based mathematical study |
| topic | cholera bacteriophage phage basic reproduction number |
| url | http://dx.doi.org/10.1080/17513758.2021.2017032 |
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