Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases
Background: Thermogenic brown and beige adipocytes are recognized for their unique capacity to consume extraordinary levels of metabolites and lipids from the blood to fuel heat-producing catabolic processes [1–7]. In humans, the functions of thermogenic adipocytes are associated with cardiometaboli...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-06-01
|
| Series: | Molecular Metabolism |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877822000436 |
| _version_ | 1818191647753633792 |
|---|---|
| author | Olivia Sveidahl Johansen Tao Ma Zachary Gerhart-Hines |
| author_facet | Olivia Sveidahl Johansen Tao Ma Zachary Gerhart-Hines |
| author_sort | Olivia Sveidahl Johansen |
| collection | DOAJ |
| description | Background: Thermogenic brown and beige adipocytes are recognized for their unique capacity to consume extraordinary levels of metabolites and lipids from the blood to fuel heat-producing catabolic processes [1–7]. In humans, the functions of thermogenic adipocytes are associated with cardiometabolic protection and improved glycemic control [8–13]. Consequently, engaging these macronutrient-consuming and energy-dissipating activities has gained attention as a promising therapeutic strategy for counteracting metabolic diseases, such as obesity and diabetes. Scope of review: In this review, we highlight new advances in our understanding of the physiological role of G protein-coupled receptors (GPCRs) in controlling thermogenic adipocyte biology. We further extend our discussion to the opportunities and challenges posed by pharmacologically targeting different elements of GPCR signaling in these highly specialized fat cells. Major conclusions: GPCRs represent appealing candidates through which to harness adipose thermogenesis. Yet safely and effectively targeting these druggable receptors on brown and beige adipocytes has thus far proven challenging. Therefore, continued interrogation across the GPCR landscape is necessary for future leaps within the field of thermogenic fat biology to unlock the therapeutic potential of adipocyte catabolism. |
| first_indexed | 2024-12-12T00:17:56Z |
| format | Article |
| id | doaj.art-09f243c37a374d1bb35246c602a07e6d |
| institution | Directory Open Access Journal |
| issn | 2212-8778 |
| language | English |
| last_indexed | 2024-12-12T00:17:56Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Metabolism |
| spelling | doaj.art-09f243c37a374d1bb35246c602a07e6d2022-12-22T00:44:48ZengElsevierMolecular Metabolism2212-87782022-06-0160101474Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseasesOlivia Sveidahl Johansen0Tao Ma1Zachary Gerhart-Hines2Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, DenmarkNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Embark Biotech ApS, Copenhagen, DenmarkNovo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Embark Biotech ApS, Copenhagen, Denmark; Center for Adipocyte Signaling, Odense, Denmark; Corresponding author. Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.Background: Thermogenic brown and beige adipocytes are recognized for their unique capacity to consume extraordinary levels of metabolites and lipids from the blood to fuel heat-producing catabolic processes [1–7]. In humans, the functions of thermogenic adipocytes are associated with cardiometabolic protection and improved glycemic control [8–13]. Consequently, engaging these macronutrient-consuming and energy-dissipating activities has gained attention as a promising therapeutic strategy for counteracting metabolic diseases, such as obesity and diabetes. Scope of review: In this review, we highlight new advances in our understanding of the physiological role of G protein-coupled receptors (GPCRs) in controlling thermogenic adipocyte biology. We further extend our discussion to the opportunities and challenges posed by pharmacologically targeting different elements of GPCR signaling in these highly specialized fat cells. Major conclusions: GPCRs represent appealing candidates through which to harness adipose thermogenesis. Yet safely and effectively targeting these druggable receptors on brown and beige adipocytes has thus far proven challenging. Therefore, continued interrogation across the GPCR landscape is necessary for future leaps within the field of thermogenic fat biology to unlock the therapeutic potential of adipocyte catabolism.http://www.sciencedirect.com/science/article/pii/S2212877822000436Brown adipose tissueG protein-coupled receptorCell signalingEnergy expenditureObesityDiabetes |
| spellingShingle | Olivia Sveidahl Johansen Tao Ma Zachary Gerhart-Hines Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases Molecular Metabolism Brown adipose tissue G protein-coupled receptor Cell signaling Energy expenditure Obesity Diabetes |
| title | Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases |
| title_full | Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases |
| title_fullStr | Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases |
| title_full_unstemmed | Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases |
| title_short | Leveraging GPCR signaling in thermogenic fat to counteract metabolic diseases |
| title_sort | leveraging gpcr signaling in thermogenic fat to counteract metabolic diseases |
| topic | Brown adipose tissue G protein-coupled receptor Cell signaling Energy expenditure Obesity Diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S2212877822000436 |
| work_keys_str_mv | AT oliviasveidahljohansen leveraginggpcrsignalinginthermogenicfattocounteractmetabolicdiseases AT taoma leveraginggpcrsignalinginthermogenicfattocounteractmetabolicdiseases AT zacharygerharthines leveraginggpcrsignalinginthermogenicfattocounteractmetabolicdiseases |